Multifunctional and multicoordinating amphiphilic polymer ligands for interfacing semiconducting, magnetic, and metallic nanocrystals with biological systems
View Patent ↗The disclosure is directed to a set of multi-coordinating imidazole- and zwitterion-based ligands suited for surface-functionalizing quantum dots (QDs). The polymeric ligands are built using a one-step nucleophilic addition reaction between poly(isobutylene-alt-maleic anhydride) and distinct amine-containing functionalities.
1. A composition comprising a polymer comprising a repeat unit (F) as represented by the following structure:
wherein the polymer further comprises a repeat unit selected from the group consisting of a repeat unit (A′), a repeat unit (A″), a repeat unit (B), and any combination thereof, as represented by the following structures:
further wherein the polymer further comprises a repeat unit selected from the group consisting of a repeat unit (G), a repeat unit (H), and a combination thereof, as represented by the following structures:
2. The composition of claim 1 wherein the polymer further comprises a repeat unit (E′) as represented by the following structure:
wherein each R is independently hydrogen or COOH, and
each R 1 is independently —H, —NO 2 , or —OH.
3. The composition of claim 1 wherein the polymer further comprises a repeat unit (E″) as represented by the following structure:
4. The composition of claim 1 wherein the polymer further comprises a repeat unit (C) as represented by the following structure:
5. The composition of claim 1 wherein the polymer further comprises a repeat unit (D), as represented by the following structure:
wherein Y has a value between one and about 100 and each R is independently selected from the group consisting of hydroxy (—OH), methoxy (—OCH 3 ), amino (—NH 2 ), azido (—N 3 ), thiol (—SH), lipoic acid, ethynyl (—C≡CH), carboxyl (—COOH), aldehyde (—C(O)H), maleimide, and biotin.
6. The composition of claim 1 wherein the polymer further comprises the repeat unit (G), as represented by the following structure:
7. The composition of claim 1 wherein the polymer further comprises the repeat unit (H), as represented by the following structure:
8. The composition of claim 1 wherein the polymer comprises the combination of:
(i) the repeat unit (F);
(ii) at least one of the repeat unit (A′) and the repeat unit (A″);
(iii) the repeat unit (B); and
(iv) at least one of the repeat unit (G) and the repeat unit (H); and
further wherein a molar ratio of the at least one of the repeat unit (A′) and the repeat unit (A″) to the repeat unit (B) is between 2:1 and 1:2.
9. A composition comprising
a nanoparticle; and
a coating encompassing the nanoparticle, the coating comprising a polymer comprising repeat unit (F) as represented by the following structure:
wherein the polymer further comprises a repeat unit selected from the group consisting of repeat unit (A′), repeat unit (A″), repeat unit (B), and any combination thereof, as represented by the following structures:
further wherein the polymer further comprises a repeat unit selected from the group consisting of a repeat unit (G), a repeat unit (H), and a combination thereof, as represented by the following structures:
10. The composition of claim 9 wherein the nanoparticle comprises a semiconductor material.
11. The composition of claim 9 wherein the nanoparticle comprises a magnetic material.
12. The composition of claim 9 wherein the nanoparticle comprises a material selected from the group consisting of Fe 3 O 4 , Fe 2 O 3 , FePt, Co, Mn-doped Fe 3 O 4 , CdSeS/ZnS, InP/ZnS, PbS, CdTe, CoPt, FeCoPt, CoFe 2 O 4 , MnO, Mn 3 O 4 , Co 3 O 4 , FeO, Ni, TiO 2 , Al 2 O 3 , CdSe, PbSe, ZrO 2 , ZnO, Au, Ag, and graphene oxide.
13. The composition of claim 9 wherein the polymer further comprises a repeat unit (E′) as represented by the following structure:
wherein each R is independently hydrogen or —COOH, and
each R 1 is independently —H, —NO 2 , or —OH.
14. The composition of claim 9 wherein the polymer further comprises a repeat unit (E″) as represented by the following structure:
15. The composition of claim 9 wherein the polymer further comprises a repeat unit (C) as represented by the following structure:
16. The composition of claim 9 wherein the polymer further comprises a repeat unit (D), as represented by the following structure:
wherein Y has a value between one and about 100 and each R is independently selected from the group consisting of hydroxy (—OH), methoxy (—OCH 3 ), amino (—NH 2 ), azido (—N 3 ), thiol (—SH), lipoic acid, ethynyl (—C≡CH), carboxyl (—COOH), aldehyde (—C(O)H), maleimide, and biotin.
17. The composition of claim 9 wherein the polymer further comprises the repeat unit (G), as represented by the following structure:
18. The composition of claim 9 wherein the polymer further comprises the repeat unit (H), as represented by the following structure:
19. The composition of claim 9 wherein the polymer comprises the combination of:
(i) the repeat unit (F);
(ii) at least one of the repeat unit (A′) and the repeat unit (A″);
(iii) the repeat unit (B); and
(iv) at least one of the repeat unit (G) and the repeat unit (H); and
further wherein a molar ratio of the at least one of the repeat unit (A′) and the repeat unit (A″) to the repeat unit (B) is between 2:1 and 1:2.