IP Library › Granted Patent US 10,047,142
Granted Patent B2
US 10,047,142 · App. 15/355,475 · Granted Aug 14, 2018

Factor VIII variants having a decreased cellular uptake

Inventors: Henriet Meems (Amsterdam, NL); Alexander Benjamin Meijer (Amsterdam, NL); Koenraad Mertens (Amsterdam, NL); Ole Hvilsted Olsen (Broenshoej, DK); Kasper Lamberth (Stenloese, DK); Peder Lisby Noerby (Birkeroed, DK); Laust Bruun Johnsen (Skodsborg, DK); Marianne Hjortnes Kjalke (Frederikssund, DK); Henning Ralf Stennicke (Kokkedal, DK); Johannes Jacobus Voorberg (Wormer, NL); Maartje Van Den Biggelaar (Amsterdam, NL)
Assignees: Novo Nordisk A/S; Sanquin Blood Supply Foundation
C07K14/755A61K38/00
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Quick Facts
Patent No.
US 10,047,142
App. No.
15/355,475
Granted
Aug 14, 2018
Kind
B2
Abstract

The present invention relates to modified coagulation factors. In particular, the present invention relates to modied Factor VIII molecules having decreased cellular uptake.

Claims (6)

1. A recombinant Factor VIII (FVIII) variant having FVIII activity, wherein the recombinant FVIII variant consists of an amino acid sequence selected from the group consisting of SEQ ID NOs: 4, 5, 7 and 8.

2. A pharmaceutical composition comprising a recombinant FVIII variant according to claim 1 .

3. A method for treating hemophilia comprising administering the recombinant FVIII variant according to claim 1 to a subject in need thereof.

4. A conjugate comprising the recombinant FVIII variant of claim 1 and a half-life extending agent selected from the group consisting of polyethylene glycol (PEG), poly sialic acid (PSA), and heparosan (HEP).

5. A pharmaceutical composition comprising the conjugate according to claim 4 .

6. A method for treating hemophilia comprising administering the conjugate according to claim 4 to a subject in need thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2018
From: NOVO NORDISK AS
To: SANQUIN BLOOD SUPPLY FOUNDATION
Reel/Frame 047199/0558 →
Priority Claims (2)
EP 10176731 · Sep 15, 2010 · regional
EP 11173768 · Jul 13, 2011 · regional
Continuity (5)
Continuation 14862934 · Sep 23, 2015
Continuation 13822942
Provisional Application 61384731 · Sep 21, 2010
Provisional Application 61507666 · Jul 14, 2011
Related Publication 20170066813A1 · Mar 9, 2017