Bondable blood-friendly polymer and preparing method thereof
A bondable blood-friendly polymer is a terpolymer or a quadripolymer at least formed by polyethylene glycol alkyl ether acrylate or polyethylene glycol alkyl ether methacrylate (I), and zwitterionic acrylic ester or zwitterionic methacrylic ester (II), and acrylic acid or a methacrylate derivative with an epoxypropyl group, an isocyanate group, a trialkoxy silane, a hydroxyalkyl group, a propargyl group or a quaternary ammonium group (III). In the present invention, the blood-friendly polymer with a potentially-bondable group has the following advantages: although the water insolubility thereof is implemented by using the hydrophobicity physical effect of an existing higher alkyl acrylate linkage, the blood friendliness of a coating is reduced due to the existence of a great number of hydrophobic chain links in the polymer; and a physical coating is slowly desolventized from the surface to be ablated in the application process of the physical coating. A disclosed bondable blood-friendly polymer coating not only can overcome these defects, but also can improve the blending property thereof. Disclosed are composition, a structure and a preparation method of the bondable blood-friendly polymer.
1. A bondable blood-friendly polymer polymerized by at least three kinds of monomers; the three kinds of monomers are:
a first monomer (I), which is a polyethylene glycol alkyl ether acrylate or a polyethylene glycol alkyl ether methacrylate;
a second monomer (II), which is a zwitterionic acrylic ester or a zwitterionic methacrylic ester; and
a third monomer (III), which has a chemical structure selected from
wherein n=2, 3, or 4;
wherein a mole ratio of the first monomer (I), the second monomer (II) and the third monomer (III) is 1-9:1-7:0.2-3.
2. The bondable blood-friendly polymer of claim 1 , wherein the first monomer (I) has a chemical structure below:
wherein R 1 is H, or CH 3 ;
R 2 is CH 3 ; and
n is 2-114.
3. The bondable blood-friendly polymer of claim 1 , wherein the second monomer (II) has a chemical structure selected from
wherein R 1 is H or CH 3 , and R 2 is CH 3 or C 2 H 5 ;
wherein R 1 is H or CH 3 , R 2 is CH 3 or C 2 H 5 , and R 3 is C 6 -C 12 ;
wherein R is CH 3 or C 2 H 5 ; and
wherein R 1 is H or CH 3 , and R 2 is CH 3 or C 2 H 5 .
4. The bondable blood-friendly polymer of claim 1 , wherein the polymer is polymerized by four kinds of monomers, the four kinds of monomers are the first monomer (I), the second monomer (II), the third monomer (III) and a fourth monomer (IV) which is a higher alkyl methacrylate or a 3-[tris (trimethylsiloxy) silyl]propyl methacrylate.
5. The bondable blood-friendly polymer of claim 4 , wherein a mole ratio of the first monomer (I), the second monomer (II), the third monomer (III) and the fourth monomer (IV) is 1-8:1-7:0.2-3:2-4.
6. A coating layer on a manufacture, wherein a material of the coating layer comprises a polymer polymerized by monomers comprising:
a first monomer (I), which is a polyethylene glycol alkyl ether acrylate or a polyethylene glycol alkyl ether methacrylate;
a second monomer (II), which is a zwitterionic acrylic ester or a zwitterionic methacrylic ester; and
a third monomer (III), which has a chemical structure selected from
wherein n=2, 3, or 4;
wherein a mole ratio of the first monomer (I), the second monomer (II) and the third monomer (III) is 1-9:1-7:0.2-3.
7. The coating layer of claim 6 , wherein the first monomer (I) has a chemical structure below:
wherein R 1 is H, or CH 3 ;
R 2 is CH 3 ; and
n is 2-114.
8. The coating layer of claim 6 , wherein the second monomer (II) has a chemical structure selected from
wherein R 1 is H or CH 3 , and R 2 is CH 3 or C 2 H 5 ;
wherein R 1 is H or CH 3 , R 2 is CH 3 or C 2 H 5 , and R 3 is C 6 -C 12 ;
wherein R is CH 3 or C 2 H 5 ; and
wherein R 1 is H or CH 3 , and R 2 is CH 3 or C 2 H 5 .
9. The coating layer of claim 6 , wherein the monomers further comprises a fourth monomer (IV), which is a higher alkyl methacrylate or a 3-[tris (trimethylsiloxy) silyl]propyl methacrylate.
10. The coating layer of claim 9 , wherein a mole ratio of the first monomer (I), the second monomer (II), the third monomer (III) and the fourth monomer (IV) is 1-8:1-7:0.2-3:2-4.
11. The coating layer of claim 6 , wherein the coating layer is coated on a manufacture made from a material of a glass, a ceramics, or a metal.
12. A method of preparing bondable blood-friendly polymer, the method comprising:
adding a first monomer (I), a second monomer (II), a third monomer (III), and a radical initiator into a solvent, wherein the first monomer (I) is a polyethylene glycol alkyl ether acrylate or a polyethylene glycol alkyl ether methacrylate, the second monomer (II) is a zwitterionic acrylic ester or a zwitterionic methacrylic ester, the third monomer (III) has a chemical structure selected from
wherein n=2, 3, or 4;
the solvent is an alcohol, a mixed solvent of alcohol and tetrahydrofuran, or dimethyl sulfoxide; and the radical initiator is azobisisobutyronitrile (AIBN), azobiscyanovaleric acid (ACVA), or benzoyl peroxide (BPO);
polymerizing the first monomer (I), the second monomer (II), and the third monomer (III) under nitrogen atmosphere at 60-70° C. for 24-45 h to obtain a polymer;
and precipitating the polymer in an anhydrous ether.
13. The method of claim 12 , wherein a mole ratio of the first monomer (I), the second monomer (II) and the third monomer (III) is 1-9:1-7:0.2-3.
14. The method of claim 12 , further comprising adding a fourth monomer (IV) into the solvent to be polymerized with the first monomer (I), the second monomer (II), and the third monomer (III), wherein the fourth monomer (IV) is a higher alkyl methacrylate or a 3-[tris (trimethylsiloxy) silyl]propyl methacrylate.
15. The method of claim 14 , wherein a mole ratio of the first monomer (I), the second monomer (II), the third monomer (III) and the fourth monomer (IV) is 1-8:1-7:0.2-3:2-4.
16. The method of claim 12 , wherein the first monomer (I) has a chemical structure below:
wherein R 1 is H, or CH 3 ;
R 2 is CH 3 ; and
n is 2-114.
17. The method of claim 12 , wherein the second monomer (II) has a chemical structure selected from
wherein R 1 is H or CH 3 , and R 2 is CH 3 or C 2 H 5 ;
wherein R 1 is H or CH 3 , R 2 is CH 3 or C 2 H 5 , and R 3 is C 6 -C 12 ;
wherein R is CH 3 or C 2 H 5 ; and
wherein R 1 is H or CH 3 , and R 2 is CH 3 or C 2 H 5 .