Ion trap mass spectrometer
An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.
1. A mass spectrometry apparatus, comprising:
a chromatograph;
a first mass spectrometer arranged downstream of said chromatograph;
a fragmentation cell for fragmenting ions from said first mass spectrometer;
a pulsed converter elongated in a linear or curved Z-direction;
an electrostatic trap elongated in a linear or curved Z-direction and comprising at least one of an image current detector and a time-of-flight detector.
2. The apparatus of claim 1 , wherein the Z-direction is curved such that said electrostatic trap comprises a cylindrical electrostatic trap.
3. The apparatus of claim 2 , wherein said cylindrical electrostatic trap further comprises a ring electrode arranged to correct radial ion displacement within said cylindrical electrostatic trap.
4. The apparatus of claim 1 , further comprising an ion source arranged sequentially between said chromatograph and said first mass spectrometer.
5. The apparatus of claim 4 , wherein said ion source comprises one of the following group:
(i) electrospray;
(ii) atmospheric pressure chemical ionization;
(iii) atmospheric pressure chemical ionization;
(iv) atmospheric pressure photo ionization;
(v) matrix assisted laser desorption and ionization;
(vi) electron impact; and
(vii) inductively coupled plasma.
6. The apparatus of claim 1 , further comprising a gaseous radio frequency ion guide arranged sequentially between said fragmentation cell and said pulsed converter.
7. The apparatus of claim 1 , wherein said chromatograph comprises one of the following group:
(i) a liquid chromatograph (LC);
(ii) a gas chromatograph (GC);
(iii) a capillary electrophoresis separator (CE); and
(iv) a tandem chromatograph, such as GC×GC, LC×LC, or LC×CE.
8. The apparatus of claim 1 , wherein said first mass spectrometer is a quadrupole mass spectrometer.
9. The apparatus of claim 1 , wherein said fragmentation cell comprises a surface for surface induced dissociation, said surface residing adjacent to an ion oscillation region of said first mass spectrometer.
10. The apparatus of claim 9 , wherein said first mass spectrometer comprises one or more excitation electrodes residing within said ion oscillation region, wherein a string of periodic short pulses for deflecting or accelerating ions are applied to at least one or said one or more excitation electrodes.
11. The apparatus of claim 1 , wherein MS-MS data generated by said apparatus is analyzed using at least one strategy of the following group:
(i) data dependent analysis where the parent mass and the duration of individual MS-MS steps are selected based on parent mass spectra;
(ii) all mass MS-MS analysis at higher acquisition speed; and
(iii) data dependent analysis wherein parent ion masses and fill-time are selected for high resolution analysis based on all-mass MS-MS analysis at a moderate resolution.
12. The apparatus of claim 1 , wherein the electrostatic trap comprises a set of analyzer electrodes having multiple sets of elongated slits forming an array of elongated volumes, each of said volumes forming a two-dimensional electrostatic field in an X-Y plane extended in said Z-direction.
13. The apparatus of claim 1 , wherein said electrostatic trap and said pulsed converter are both multiplexed, and said apparatus further comprises multiple ion sources multiplexed between said multiplexed pulse converter.