IP Library › Granted Patent US 10,052,318
Granted Patent B2
US 10,052,318 · App. 14/278,573 · Granted Aug 21, 2018

Glutamate agents in the treatment of mental disorders

Inventors: Vladimir Coric (Madison, CT); John H. Krystal (Woodbridge, CT); Gerard Sanacora (Guilford, CT)
Assignee: YALE UNIVERSITY
A61K31/485A61K31/13A61K31/198A61K31/425A61K31/428A61K31/43A61K31/545A61K45/06
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Quick Facts
Patent No.
US 10,052,318
App. No.
14/278,573
Granted
Aug 21, 2018
Kind
B2
Abstract

Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator and a serotonin reuptake inhibitor. Pharmaceutical composition comprising a serotonin reuptake inhibitor and a glutamate modulator are also provided.

Claims (6)

1. A method of treating a mental disorder in an individual in need thereof comprising administering to said individual a pharmaceutical composition comprising an effective amount of riluzole alone for treating said mental disorder, wherein said mental disorder is social anxiety disorder or panic disorder.

2. The method according to claim 1 wherein said mental disorder is social anxiety disorder.

3. The method according to claim 1 wherein said mental disorder is panic disorder.

4. The method according to claim 1 wherein said composition is administered once daily.

5. The method according to claim 2 wherein said composition is administered once daily.

6. The method according to claim 3 wherein said composition is administered once daily.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 10, 2018
From: CORIC, VLADIMIR; KRYSTAL, JOHN H.; SANACORA, GERARD
To: YALE UNIVERSITY
Reel/Frame 046308/0120 →
Continuity (7)
Division 11399188 · Apr 5, 2006
Provisional Application 60668735 · Apr 5, 2005
Provisional Application 60669774 · Apr 7, 2005
Provisional Application 60690187 · Jun 13, 2005
Provisional Application 60694621 · Jun 27, 2005
Provisional Application 60756472 · Jan 4, 2006
Related Publication 20140249173A1 · Sep 4, 2014