IP Library › Granted Patent US 10,053,431

Granted Patent B2

US 10,053,431 · App. 15/037,240 · Granted Aug 21, 2018

Tetrahydro-benzodiazepinones

Inventors: Shaoqing Chen (Bridgewater, NJ); Andrew F. Donnell (West Windsor, NJ); Robert Francis Kester (West Orange, NJ); Kang Le (Sugar Land, TX); Yan Lou (Pleasanton, CA); Christophe Michoud (New York, NY); Stacy Remiszewski (Washington, NJ); Kenneth C. Rupert (Bedminster, NJ); Martin Weisel (Mannheim, DE)

Assignee: Hoffmann-La Roche Inc.

C07D243/14 C07D243/12 C07D401/06 C07D401/14 C07D403/06 C07D403/12 C07D405/06 C07D405/14 C07D413/06 C07D417/12 C07D487/08

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Patent No.: US 10,053,431
App. No.: 15/037,240
Granted: Aug 21, 2018
Kind: B2

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Abstract

Disclosed are compounds of Formula I, or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R 1 , R 2 , R 3 , R 4 and R 5 are as described in this application, and methods of using said compounds in the treatment of cancer.

Claims (451)

1. A compound, selected from the group consisting of: Cyclic-5-[(S)-5-(2-Amino-ethyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride; Cyclic-5-[(S)-5-(3-Amino-propionyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride; Cyclic-5-[(S)-5-(3-amino-propyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride; Cyclic-5-[(S)-5-(4-Amino-butyryl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride; and Cyclic-5-[(S)-5-(5-amino-pentanoyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride, or a pharmaceutically acceptable salt thereof.

2. A compound, selected from the group consisting of:

(S)-2-Methylamino-N—((S)-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide hydrochloride,

(S)—N—((S)-5-Acetyl-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-methylamino-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-5-(3-methyl-butyryl)-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)-2-Methylamino-N—((S)-1-naphthalen-1-ylmethyl-2-oxo-5-phenylacetyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide hydrochloride,

(S)-2-Methylamino-N—((S)-5-methyl-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-5-(3-methyl-butyl)-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)-2-Methylamino-N—((S)-1-naphthalen-1-ylmethyl-2-oxo-5-phenethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide trifluoroacetate,

(S)-2-Methylamino-N—[(S)-5-(3-methyl-butyryl)-1-(2-methyl-naphthalen-1-ylmethyl)-2oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-naphthalen-1ylmethyl)-2-oxo-5-(pyridine-4-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)—N—[(S)-5-[2-(2-methoxy-ethoxy)-acetyl]-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-(2-Carbamoyl-acetyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-2-methylamino-N—{(S)-1-(2-methyl-naphthalen-1-ylmethyl)-5-[2-(4-methyl-piperazin-1-yl)-acetyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl}-propionamide hydrochloride,

(S)—N—[(S)-5-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-acetyl}-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-5-(2-pyridin-4-yl-acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide dihydrochloride,

(S)—N—[(S)-5-(4-Methanesulfonyl-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-5-(5-oxo-hexanoyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

methyl 6-((S)-3-((S)-2-(methylamino)propanamido)-5-((2-methylnaphthalen-1-yl)methyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-1-yl)-6-oxohexanoate hydrochloride,

(S)—N—[(S)-5-(4-Acetyl-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-5-(3,4,5-trimethoxy-benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(2-cyclohexylacetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—{(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-[4-(2,2-dimethyl-propionyl)-benzoyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl}-2-methylamino-propionamide hydrochloride,

(S)—N—{(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-5-[4-(2,2,2-trifluoro-1,1-dihydroxy-ethyl)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl}-2-methylamino-propionamide trifluoroacetate,

(S)—N—[(S)-5-(3-Acetyl-benzoyl)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-(4-nitro-benzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-(4-nitro-butyryl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-[2-(4-Acetyl-phenyl)-acetyl]-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-cyanobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—[(S)-5-(2-Adamantan-1-yl-acetyl)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

methyl 5-[[(3S)-1-[3-(9H-fluoren-9-ylmethoxycarbonylamino)propanoyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzodiazepin-5-yl]methyl]-6-methoxy-naphthalene-2-carboxylate hydrochloride,

(S)—N—[(S)-5-acetyl-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

5-[(S)-3-((S)-2-methylamino-propionylamino)-5-(2-methyl-naphthalen-1-ymethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1yl]-5-oxo-pentanoic acid hydrochloride,

4-[(S)-3-((S)-2-methylamino-propionylamino)-5-(2-methyl-naphthalen-1-ylmethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-yl]-4-oxo-butyric acid hydrochloride,

(S)-3-((S)-2-methylamino-propionylamino)-5-(2-methyl-naphthalen-1-ylmethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-carboxylic acid methylamide hydrochloride,

(S)—N—[(S)-5-methanesulfonylmethanesulfonyl-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide trifluoroacetate,

(S)—N—[(S)-5-methanesulfonyl-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-3-((S)-2-methylamino-propionylamino)-5-(2-methyl-naphthalen-1-ylmethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-carboxylic acid methyl ester hydrochloride,

(S)—N—[(S)-1-benzyl-5-(3-methyl-butyryl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(2-methoxy-benzyl)-5-(3-methyl-butyryl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b[1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-5-(3-methyl-butyryl)-2-oxo-1-phenethyl-2,3,4,5-tetrahydro-1H-benzo[b[1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)—N—[(S)-1-(2-Methoxy-naphthalen-1-ylmethyl)-5-(3-methyl-butyryl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b[1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-5-(3-methyl-butyryl)-1-(1-naphthalen-1-yl-ethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)—N—[(S)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-5-(3-methyl-butyryl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b[1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-5-(5-oxo-hexanoyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

4-[(S)-5-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-3-((S)-2-methylamino-propionylamino)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-carbonyl]-benzoic acid methyl ester hydrochloride,

4-[(S)-5-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-3-((S)-2-methylamino-propionylamino)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-carbonyl]-benzoic acid hydrochloride,

4-[(S)-5-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-3-((S)-2-methylamino-propionylamino)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-carbonyl]-benzamide hydrochloride,

4-[(S)-5-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-3-((S)-2-methylamino-propionylamino)-4-oxo-2,3,4,5-tetrabydro-benzo[b][1,4]diazepin-1-carbonyl]-N-cyclohexylmethyl-benzamide hydrochloride,

(S)—N—{(S)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-5-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl}-2-methylamino-propionamide hydrochloride,

(S)—N—{(S)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-5-(4-(1-hydroxy-ethyl)-benzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl}-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-(Adamantan-1-carbonyl)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-(4-Amino-benzoyl)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-Azetidine-2-carbonxylic acid[(S)-5-(4-acetyl-benzoyl)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[[b][1,4]diazepin-3-yl]-amide hydrochloride,

(R)—N—[(S)-5-(4-acetyl-benzoyl)-1-(6-bromo-2-methoxyl-napthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-(4-Acetyl-benzoyl)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-dimethylamino-propionamide,

(S)—N—[(S)-5-(4-acetyl-benzoyl)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-amino-propionamide,

(S)—N—[(S)-5-(4-Acetyl-benzoyl)-1-(2-naphthalen-1-yl-ethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-(4-amino-benzoyl)-1-(2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-(4-acetylamino-benzoyl)-1-(2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

5-[(S)-5-(4-Acetyl-benzoyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalen-2-carboxylic acid methyl ester hydrochloride,

5-[(S)-5-(4-acetyl-benzoy)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalen-2-carboxylic acid hydrochloride,

5-[(S)-5-(4-acetyl-benzoy)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalen-2-carboxylic acid hydroxyamide trifluoroacetate,

6-Methoxy-5-[(S)-3((S)-2-methylamino-propionylamino)-2-oxo-5-(5-oxo-hexanoyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-naphthalene-2-carboxylic acid methyl ester hydrochloride,

6-Methoxy-5-[(S)-3((S)-2-methylamino-propionylamino)-2-oxo-5-(5-oxo-hexanoyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-naphthalene-2-carboxylic acid hydrochloride,

5-[(S)-5-[4-(9H-Fluoren-9-ylmethoxycarbonylamino)-butyryl]-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid methyl ester hydrochloride,

5-[(S)-5-(4-Amino-butyryl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid methyl ester hydrochloride,

5-[(S)-5-(4-Amino-butyryl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid hydrochloride,

Cyclic-5-[(S)-5-(4-Amino-butyryl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride,

5-[(S)-5-(5-amino-pentanoyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][[1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid methyl ester hydrochloride,

5-[(S)-5-(5-amino-pentanoyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid hydrochloride,

Cyclic-5-[(S)-5-(5-amino-pentanoyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride,

5-[(S)-5-[4-(9H-Fluoren-9-ylmethoxycarbonylamino)-benzoyl]-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid methyl ester hydrochloride,

5-[(S)-5-(4-Amino-benzoyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid methyl ester hydrochloride,

5-[(S)-5-(4-Amino-benzoyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid hydrochloride,

Cyclic-5-[(S)-5-(3-amino-propyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][[1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride,

Cyclic-5-[(S)-5-(2-Amino-ethyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride,

6-[(S)-3-((S)-2-Methylamino-propionylamino)-5-(2-methyl-naphthalen-1-ylmethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-6-oxo-hexanoic acid hydrochloride,

5-[(S)-5-(3-Amino-propionyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid methyl ester hydrochloride,

5-[(S)-5-(3-Amino-propionyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic acid hydrochloride,

Cyclic-5-[(S)-5-(3-Amino-propionyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride,

(S)—N—((S)-5-(4-Acetylbenzoyl)-1-((2-methylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-aminopropanamide hydrochloride,

(S)-2-Amino-N—((S)-5-(4-aminobenzoyl)-1-((2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)propanamide hydrochloride,

(S)-2-(Methylamino)-N—((S)-1-((2-methylnaphthalen-1-yl)methyl)-5-(4-nitrobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)propanamide hydrochloride,

(S)—N—((S)-5-(4-Aminobenzoyl)-1-((2-methylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-N-methyl-2-(methylamino)propanamide hydrochloride,

(R)—N—((S)-5-(4-Acetylbenzoyl)-1-((2-methylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-Acetylbenzoyl)-2-oxo-1-((2-(2,2,2-trifluoroethoxy)naphthalen-1-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((2-(difluoromethoxy)naphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-(benzo[d]isoxazol-3-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((6-bromobenzo[d]isoxazol-3-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-2-oxo-1-((2-(2,2,2-trifluoroethoxy)naphthalen-1-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-aminopropanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((2-(difluoromethoxy)naphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-aminopropanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-aminopropanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-(benzo[d]isoxazol-3-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-aminopropanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((2-(difluoromethoxy)naphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

4-(((S)-5-(4-Acetylbenzoyl)-3-((S)-2-(methylamino)propanamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-1-yl)methyl)-3-(2,2,2-trifluoroethoxy)quinoline 1-oxide hydrochloride,

(S)—N—((S)-5-(4-Aminobenzoyl)-1-(benzo[d]isoxazol-3-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

Methyl 4-((S)-5-(benzo[d]isoxazol-3-ylmethyl)-3-((S)-2-(methylamino)propanamido)-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-1-carbonyl)benzoate hydrochloride,

(S)—N—((S)-1-((5-Bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-cyanobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-Cyanobenzoyl)-1-((2-(difluoromethoxy)naphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-1-((6-Bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-methylbenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(isoxazole-5-carbonyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-5-(tetrahydro-2H-pyran-4-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-Bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-5-(2-(pyridin-3-yl)acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]di azepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-5-(pyrazine-2-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetamidobenzoyl)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide trifluoroacetate,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(1-methyl-1H-pyrazole-3-carbonyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide trifluoroacetate,

(S)—N—((S)-5-Benzyl-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide trifluoroacetate,

(S)—N—((S)-1-((6-Bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-cyanobenzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide trifluoroacetate,

(S)—N—((S)-5-(4-Acetylbenzoyl)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)butanamide hydrochloride,

(S)—N—((S)-5-(4-Acetylbenzoyl)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(ethylamino)propanamide hydrochloride,

(S)—N—((S)-1-((5-Bromo-2-methoxynaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((2-methoxynaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((2-(Difluoromethoxy)naphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—[(S)-1-(6-Bromo-2-(d3-methoxy)-naphthalen-1-ylmethyl)-5-(4-cyano-benzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(6-Bromo-2-(d3-methoxy)-naphthalen-1-ylmethyl)-2-oxo-5-(2-pyridin-3-yl-acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-5-(2-tetrahydro-pyran-4-yl-acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(5-Bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-5-(2-tetrahydro-pyran-4-yl-acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(5-Bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-5-(2-pyridin-3-yl-acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-5-(pyridine-2-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-nicotinoyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-5-(2-(pyridin-2-yl)acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-benzoyl-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(1-methyl-1H-pyrazole-4-carbonyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—[(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-(2-fluoro-benzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(3-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(3-cyanobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-(methylsulfonyl)benzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(3-methoxypropanoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(2-cyanobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—[(S)-5-Benzoyl-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—((S)-5-acetyl-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(5-methylfuran-2-carbonyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][[1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-5-(4-(trifluoromethyl)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—[(S)-1-(5-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-4fluoro-benzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-1-(5-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-(4-methyl-benzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—{(S)-1-(5-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-[4-(1-hydroxy-ethyl)-benzoyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl}-2-methylamino-propionamide,

(S)—N—{(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-[4-(1-hydroxy-1-methyl-ethyl)-benzoyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl}-2-methylamino-propionamide trifluoroacetate,

4[(S)-3-((S)-2-Methylamino-propionylamino)-5-(2-methyl-naphthalen-1-ylmethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carbonyl]-benzoic acid methyl ester hydrochloride,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-5-(2-1H-tetrazol-5-yl-acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-5-(2-tetrahydro-pyran-4-yl-acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)—N—[(S)-5-(4-Cyano-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide,

(S)—N—[(S)-5-(2-Cyclohexyl-acetyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-(4-Chloro-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide,

(S)—N—[(S)-5-(3-Acetyl-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-5-(2-pyridin-3-yl-acetyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide,

(S)—N—[(S)-5-(4-Fluoro-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide,

(S)—N—[(S)-5-(3-Amino-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide,

(S)-2-Methylamino-N—[(S)-5-(4-methyl-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)—N—[(S)-5-(4-Methoxy-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochoride,

4-[(S)-3-((S)-2-methylamino-propionylamino)-5-(2-methyl-naphthalen-1-ylmethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carbonyl]-benzoic acid hydrochloride,

(S)—N—[(S)-5-(4-Acetylamino-benzenesulfonyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-ylmethyl)-5-methylsulfamoyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)—N—[(S)-5-(4-Acetyl-benzenesulfonyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-ylmethyl)-5-(4-nitro-benzenesulfonyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,

(S)—N—[(S)-5-Benzenesulfonyl-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-(4-Methoxy-benzenesulfonyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

3-[(S)-3-((S)-2-Methylamino-propionylamino)-5-(2-methyl-naphthalen-1-ylmethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carbonyl]-benzamide hydrochloride,

(S)—N—[(S)-5-Dimethylsulfamoyl-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)—N—[(S)-5-(2-Acetyl-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide,

(S)—N—[(S)-5-(4-Hydroxymethyl-benzoyl)-1-(2-methyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(2 S)—N-((3 S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-(1-hydroxyethyl)benzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(2S)—N-((3S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-(1-hydroxyethyl)benzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(2S)—N-[(3 S)-1-(4-acetylbenzoyl)-5-[2-(naphthalen-1-ylamino)-2-oxoethyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide; 2,2,2-trifluoroacetic acid,

(2S)—N-[(3S)-1-(4-acetylbenzoyl)-4-oxo-5-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide; 2,2,2-trifluoroacetic acid,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-nitrobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-N-methyl-2-(methylamino)propanamide hydrochloride,

(2S)—N-[(3S)-1-(4-acetylbenzoyl)-5-[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide; 2,2,2-trifluoroacetic acid,

(2S)—N-[5-(1-adamantylmethyl)-1-[(2-methoxynaphthalen-1-yl)methyl]-2,4-dioxo-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide,

(2S)—N-[5-(1-adamantylmethyl)-1-[(2-methoxynaphthalen-1-yl)methyl]-2,4-dioxo-1,5-benzodiazepin-3-yl]-2-aminopropanamide,

(2S)—N-[5-(1-adamantylmethyl)-1-[(2-methoxynaphthalen-1-yl)methyl]-2,4-dioxo-1,5-benzodiazepin-3-yl]-2-(methylamino)butanamide,

(2S)—N-(1-methyl-5-((2-methylnaphthalen-1-yl)methyl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)butanamide,

(2S)-2-(methylamino)-N-(1-((2-methylnaphthalen-1-yl)methyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)butanamide,

(2S)-2-(methylamino)-N-(1-((2-methylnaphthalen-1-yl)methyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)propanamide,

(2S)—N-[(3S)-1-(4-aminophenyl)sulfonyl-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide; hydrochloride,

(2S)—N-[(3S)-1-[3-(1-hydroxyethyl)benzoyl]-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide; hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide 2,2,2-trifluoroacetate,

(S)—N—((S)-5-(4-aminobenzoyl)-7-chloro-1-((2-methylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-aminobenzoyl)-7-chloro-1-((2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-aminobenzoyl)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-7-chloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-aminobenzoyl)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-7-chloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-(4-acetylbenzoyl)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-7-chloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-7-chloro-5-(4-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-7-chloro-5-(4-cyanobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(2S)—N-(1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2,4′-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(2S)—N-(1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-7-chloro-5-(4-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][[1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-7-chloro-5-(4-cyanobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(2S)—N-(1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(ethylamino)butanamide,

(2S)-2-amino-N-(1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)butanamide,

(2S)—N-(1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(ethylamino)butanamide,

(S)—N—((S)-1-((6-bromo-2-(2,2,2-trifluoroethoxy)naphthalen-1-yl)methyl)-7-chloro-5-(4-cyanobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-(2,2,2-trifluoroethoxy)naphthalen-1-yl)methyl)-7-chloro-5-(4-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(2S)-2-amino-N-(1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)butanamide,

(2S)—N-(1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(2-hydroxyethylamino)butanamide,

(S)—N—((S)-7-chloro-5-(4-cyanobenzoyl)-1-((2-(difluoromethoxy)naphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-chloro-1-((2-(difluoromethoxy)naphthalen-1-yl)methyl)-5-(4-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(2S)—N-[(3S)-1-(1H-indazole-5-carbonyl)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide,

(S)—N—((S)-7-cyano-5-(4-cyanobenzoyl)-1-((2-(difluoromethoxy)naphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-7-cyano-5-(4-cyanobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-7-cyano-5-(4-cyanobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(2S)—N-[(3S)-1-(1H-indole-5-carbonyl)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide,

(2S)—N-[(3S)-1-(1H-indole-4-carbonyl)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide,

(2S)—N-[(3S)-1-(1H-indazole-4-carbonyl)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide,

(2S)—N-[(3S)-1-[2-[(1S)-1-hydroxyethyl]benzoyl]-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;

(2S)—N-[(3S)-1-[2-[(1R)-1-hydroxyethyl]benzoyl]-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(ethylamino)propanamide,

(S)—N—((S)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-7-cyano-5-(4-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-cyano-1-((2-(difluoromethoxy)naphthalen-1-yl)methyl)-5-(4-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(2S)—N-[(3S)-1-(1H-indole-6-carbonyl)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide,

(2S)—N-[(3S)-1-[2-[(1S)-1-hydroxyethyl]benzoyl]-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;

(2S)—N-[(3S)-1-[2-[(1R)-1-hydroxyethyl]benzoyl]-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-7-cyano-5-(4-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(ethylamino)butanamide hydrochloride,

(S)—N—((S)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(ethylamino)propanamide hydrochloride,

(S)—N—((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(ethylamino)butanamide hydrochloride,

(2S)—N-[(3S)-1-(1H-indazole-6-carbonyl)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide,

(S)—N—((S)-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-7-cyano-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(2S)—N-[(3S)-7-cyano-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-5-(2-methylsulfinylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide; 2,2,2-trifluoroacetic acid,

(S)—N—((S)-5-(4-acetylbenzoyl)-7-cyano-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-cyano-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-5-(4-fluorobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-cyano-1-((1-methyl-1H-indazol-3-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-cyano-1-((2-methylnaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-cyano-1-((2-methoxynaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-8-cyano-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-cyano-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide dihydrochloride,

(S)—N—((S)-5-acetyl-7-cyano-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-cyano-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-2-oxo-5-(tetrahydro-2H-pyran-4-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-8-cyano-1-((2-methoxynaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-8-cyano-1-((2-methylnaphthalen-1-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-cyano-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-5-(3-methoxypropanoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-7-cyano-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-5-isonicotinoyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide dihydrochloride,

(S)—N—((S)-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-8-cyano-5-(2-(methylsulfonyl)acetyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-acetyl-7-cyano-1-((5-cyano-2-cyclopropylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N—((S)-5-acetyl-1-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(2S)—N-[(3S)-1-(4-aminobenzoyl)-5-[[2-(2-fluoroethoxy)naphthalen-1-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propananiide; hydrochloride,

(S)—N—((S)-5-acetyl-1-((5-bromo-2-methoxynaphthalen-1-yl)methyl)-7-cyano-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-7-cyano-1-((3-cyclopropylquinolin-4-yl)methyl)-2-oxo-5-(tetrahydro-2H-pyran-4-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-7-cyano-1-((3-cyclopropylquinolin-4-yl)methyl)-5-isonicotinoyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-5-acetyl-7-cyano-1-((5-cyano-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-5-acetyl-1-((3-cyclopropylquinolin-4-yl)methyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-1-((3-cyclopropylquinolin-4-yl)methyl)-2-oxo-5-(tetrahydro-2H-pyran-4-carbonyl)-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-1-((3-cyclopropylquinolin-4-yl)methyl)-5-(3-methoxypropanoyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-1-((3-cyclopropylquinolin-4-yl)methyl)-5-isonicotinoyl-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-1-((3-cyclopropylquinolin-4-yl)methyl)-5-(2-(methylsulfonyl)acetyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-1-((3-cyclopropylquinolin-4-yl)methyl)-5-(3-(methylsulfonyl)propanoyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N—((S)-5-acetyl-1-((5-cyano-2-cyclopropylnaphthalen-1-yl)methyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide,

(S)—N-((2S,3S)-1-acetyl-5-(2-(2,6-difluorophenylamino)-2-oxoethyl)-2-methyl-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(S)—N-((2S,3S)-1-acetyl-2-methyl-4-oxo-5-(2-oxo-2-(phenylamino)ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

Cyclic-5-[(S)-5-(3-Amino-acetyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide,

Cyclic-5-[(S)-5-(3-Amino-pentanoyl)-3-((S)-2-methylamino-propionylamino)-2-oxo-2,3,45-tetrahydro-benzo[b][1,4]diazepin-1-ylmethyl]-6-methoxy-naphthalene-2-carboxylic amide hydrochloride and

(2S)—N-((2S,3S)-1-acetyl-5-(2-(2,6-difluorophenylamino)-2-oxo-1-phenylethyl)-2-methyl-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

or a pharmaceutically acceptable salt thereof.

3. A compound, selected from the group consisting of:

(R)—N—((S)-5-(4-Acetylbenzoyl)-1-((2-methylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydr 1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride,

(R)—N—[(S)-5-(4-acetyl-benzoyl)-1-(6-bromo-2-methoxyl-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride,

(S)-2-(Methylamino)-N—((S)-1-((2-methylnaphthalen-1-yl)methyl)-5-(4-nitrobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)propanamide hydrochloride,

(S)-2-Amino-N—((S)-5-(4-aminobenzoyl)-1-((2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)propanamide hydrochloride,

(S)-2-Methylamino-N—((S)-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide hydrochloride,

(S)-2-Methylamino-N—((S)-1-naphthalen-1-ylmethyl-2-oxo-5-phenethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide trifluoroacetate,

(S)-2-methylamino-N—((S)-1-naphthalen-1-ylmethyl-2-oxo-5-phenylacetyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide hydrochloride,

(S)-2-Methylamino-N—((S)-5-methyl-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide hydrochloride,

(S)-2-Methylamino-N—[(S)-1-(2-methyl-naphthalen-1-naphthalen-I ylmethyl)-2-oxo-5-(pyridine-4-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-propionamide hydrochloride,