Pyrrolopyrimidine derivatives as TAM inhibitors

1. A compound having Formula IVa, IVb, IVc, IVd, or IVe:

or a pharmaceutically acceptable salt thereof, wherein

R 1 is H, halo, CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, OR a1 , SR a1 C(O)R b1 , C(O)NR c1 R d1 ,C(O)OR a1 ,OC(O)R b1 , OC(O)NR c1 R d1 , NR c1 R d1 , NR c1 OR d1 , NR c1 C(O)R b1 , NR c1 C(O)OR b1 , NR c1 C(O)NR c1 R d1 NR c1 S(O)R b1 , NR c1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , S(O) 2 NR c1 R d1 , C 3-7 cycloalkyl, phenyl, 5-6membered heteroaryl, 4-6 membered hererocycloalkyl, C 3-7 cycloalkyl-C 1-3 alkylene, 5-6 membered heteroaryl-C 1-3 alkylene, or 4-6 membered heterocycloalkyl-C 1-3 alkylene; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, C 3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-3 alkylene, phenyl-C i-3 alkylene, 5-6 membered heteroaryl-C 1-3 alkylene, and 4-6 membered heterocycloalkyl-C 1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 independently selected R 11 groups;

R 2 is H, halo, OH, CN, C 1-4 alkyl, C 1-4 haloalkyl, C 1-6 alkoxy, C 1-4 haloalkoxy, amino, C 1-6 alkylamine, or di(C 1-6 alkyl)amino;

each R 7 is independently selected from halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, CN, NO 2 , Cy, —C 1-4 alkylene-Cy, OR a , SR a , C(O)R b , C(O)NR c R d , C(O)OR a , OC(O)R b , OC(O)NR c R d , NR c R d , NR c OR d , NR c C(O)R b , NR c C(O)OR b , NR c C(O)NR c R d ,C(═NR e )R b , C(═NR e )NR c R d , NR c C(═NR e )NR c R d , NR c S(O) 2 R b , NR c S(O) 2 R b , NR c S(O) 2 NR c R d , S(O)R b , S(O)NR c R d S(O) 2 R b and S(O) 2 NR c R d ; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-4 haloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R 8 groups;

each R 8 is independently selected from halo, CN, NO 2 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy 2 , —C 1-4 alkylene-Cy 2 , OR a2 ,SR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 ,NR c2 R d2 , NR c2 OR d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2 , C(═NR e )R b2 , C(═NR e )NR c2 R d2 , NR c2 C(═NR e )NR c2 R d2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R b2 , NR c2 S(O) 2 NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 S(O) 2 NR c2 R d2 ; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-4 haloalkyl are each optionally substituted with 1 ,2, 3 , or 4 independently selected R g groups;

Z is C 1-6 alkyl, C 1-6 haloalkyl, or —C 1-6 alkylene-Z 1 ;

Z 1 is CN, Cy 3 , OR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R d3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)OR b3 , NR c3 C(O)NR c3 R d3 , NR c3 S(O)R b3 , NR c3 S(O) 2 R b3 , NR c3 S(O) 2 NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , or S(O) 2 NR c3 R d3 ;

each R 11 is independently selected from OH, NO 2 , CN, halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl,C 1-6 alkoxy, C 1-6 haloalkoxy, cyano-C 1-3 alkykl, HO—C 1-3 alkyl, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, thio, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, carbamyl, C 1-6 alkylcarbamyl, di(C 1-6 alkyl)carbamyl, carboxy, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, aminosulfonyl, C 1-6 alkylaminosulfonyl, di(C 1-6 alkyl)aminosulfonyl, aminosulfonylamino, C 1-6 alkylaminosulfonylamino, di(C 1-6 alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6 alkylaminocarbonylamino, di(C 1-6 alkyl)aminocarbonylamino, C 3-7 cycloalky, phenyl, 5-6 membred heteroaryl, 4-6 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-3 alkylene, phenyl-C 1-3 alkylene, 5-6 membered heteroaryl-C 1-3 alkylene, and 4-6 membered heterocycloalkyl-C 1-3 alkylene; wherein said C 1-6 alkyl, C 3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-3 alkylene, phenyl-C 1-3 alkylene, 5-6 membered heteroaryl-C 1-3 alkylene, and 4-6 membered heterocycloalkykl-C 1-3 alkylene are each optionally substituted with 1, 2, 3 , or 4 groups independently selected from OH, CN, halo, C 1-4 alkyl, C 1-3 haloalkyl, C 1-4 alkoxy, C 1-3 haloalkoxy, cyano-C 1-3 alkyl, HO—C 1-3 alkyl, amino, C 1-4 alkylamino, di(C 1-4 alkyl)amino, C 1-4 alkysulfinyl, C 1-4 alkoxycarbonyl, C 1-4 alkycarbonylamino, C 1-4 alkyl)carbamyl, carboxy, C 1-4 alkylcarbonyl, C 1-4 alkoxycarbonyl, C 1-4 alkylcarbonylamino, C 1-4 alkylsulfonylamino, aminosulfonyl, C 1-4 alkylaminosulfonyl, and di(C 1-4 alkyl)aminosulfonyl;

each Cy is independently selected from 3-12 membered cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, and 4-12 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3 , or 4 independently selected R 8 groups;

each Cy 1 is independently selected from 3-7 membered cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected R 11 groups;

each Cy 2 is independently selected from 3-7 membered cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected R g groups;

each Cy 3 is independently selected from 3-7 membered cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4 -6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3 , or 4 independently selected from halo, OH, CN, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkkoxy, C 1-3 haloalkoxy, amino, C 1-3 alkylamine, and di(C 1-3 alkyl)amino;

each R a , R c , and R d is independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy, and —C 1-4 alkylene-Cy; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-4 haloalkyl are each optionally substituted with 1, 2, 3 , or 4 independently selected R 8 groups;

each R b is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy, and —C 1-4 alkylene-Cy; wherein said C 1-6 alkyl, C 2-6 aldenyl, C 2-6 alkynyl, and C 1-4 haloalkyl are each optionally substituted with 1, 2, 3 , or 4 independently selected R 8 groups; alternatively, any R c and R d attache to the same N atom, together with the N atom to which they are attached, from a 4-6 membered heterocycloalkyl group or a 5-6 membered heteroaryl group, each optionally substituted with 1, 2, 3 independently selected R 8 groups;

each R e is independently selected from H, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkylthio, C 1-6 alkylsulfonyl, C 1-6 alkylcarbonyl, C 1-6 alkylaminosulfonyl, carbamyl, C 1-6 alkylcarbamyl, di(C 1-6 alkyl) carbamyl,aminosulfonyl, C 1-6 alkylaminosulfonyl, and di(C 1-6 alkyl)aminsosulfonyl;

R a1 ,R c1 ,and R d1 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-4 haloalkyl, Cy 1 , and —C 1-4 alkylene-Cy 1 ; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-4 haloalkyl are each optionally substituted with 1, 2, 3, or 4independently selected R 11 groups;

R b1 is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy 1 , and —C 1-4 alkylene-Cy 1 ; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-4 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 11 groups; or alternatively, any R c1 and R d1 attached to the same N atom, together with the N atom to which they are attached, from a 4-, 5-, 6-, 7-membered heterocycloalkyl group optionally substitusted with 1, 2 or 3 independently selected R 11 groups;

each R a2 , R c2 , and R d2 are independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy 2 , and —C 1-4 alkylene-Cy 2 ; wherein said C 1-6 alkyl, C 2-6 alkynyl, C 2-6 alkynyl, and C 1-4 haloalkyl are each optionally substituted with 1, 2, 3, or 4independently selected R g groups;

each R b2 is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy 2 ,and —C 1-4 alkylene-Cy 2 ; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-4 haloalkyl are each optionally substituted with 1, 2, 3, or 4independently selected R g groups; or alternatively, and R c2 and R d2 attached to the same N atom, together with the N atom to which they are attached, from a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2or 3independently selected R g groups;

R a3 , R c3 , and R d3 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy 3 , and —C 1-4 alkylene-Cy 3 ;

R b3 is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalyly, Cy 3 , and —C 1-4 alkylene-Cy 3 ; and

each R g is independently selected from OH, NO 2 , CN, halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, cycano-C 1-3 alkyl, HO—C 1-3 alkyl, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, thio, C 1-6 alkylthio, C 1-6 alkysulfinyl, C 1-6 alkysulfonyl, carbamyl, C 1-6 alkylcarbamyl, di(C 1-6 alkyl)carbamyl, carboxy, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, aminosulfonyl, C 1-6 alkkylaminosulfonyl, di(C 1-6 alkyl)aminosulfonyl, aminosulfonylamino, C 1-6 alkylaminosulfonylamino, di(C 1-6 alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6 alkylaminocarbonylamino, and di(C 1-6 alkyl)aminocarbonylamino.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is H or NR c1 R d1 .

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R a1 , R c1 , and R d1 are each independently selected from H, C 1-6 alkyl, and Cy 1 ; and R b1 is C 1-6 alkyl or Cy 1 .

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each Cy 1 is independently selected from 3-7 membered cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl, each of which is optionally substituted by 1 or 2 independently selected R 11 groups.

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 11 is independently selected from OH, CN, halo, C 1-6 alkyl, C 1-4 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, cyano-C 1-3 alkyl, HO—C 1-3 alkyl, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, C 1-6 alkylsulfonyl, carbamyl, C 1-6 alkylcarbamyl, di(C 1-6 alkyl)carbamyl, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, aminosulfonyl, C 1-6 alkylaminosulfonyl, di(C 1-6 alkyl)aminosulfonyl, C 3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-3 alkylene, phenyl-C 1-3 alkylene, 5-6 membered heteroaryl-C 1-3 alkylene, and 4-6 membered heterocycloalkyl-C 1-3 alkylene.

6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is H, methylamino, ethylamino, isopropylamino, n-butylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino, 1-ethyl-1H-imidazol-4-yl-amino, 1-methyl -1H-pyrazol-4-yl-amino, and 4-(morpholinylmethyl)phenylamino.

7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is H or C 1-4 alkyl.

8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 7 is independently selected from C 1-6 alkyl, CN, OH, NR c R d , —CH 2 —R 8 , Cy, and —CH 2 —Cy.

9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R a , R c and R d is independently selected from H, C 1-6 alkyl, C 1-4 haloalkyl, and Cy; wherein said C 1-6 alkyl and C 1-4 haloalkyl are each optionally substituted by 1, 2, 3, or 4 independently selected R 8 groups; and each R b is independently selected from C 1-6 alkyl, C 1-4 haloalkyl, and Cy; wherein said C 1-6 alkyl and C 1-4 haloalkyl are each optionally substituted by 1, 2, 3, or 4 independently selected R 8 groups.

10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each Cy is independently selected from azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, phenyl, imidazolyl, pyridinyl, imidazo[1,2-a]pyridinyl, and imidazo[4,5-b]pyridinyl; each of which is optionally substituted by 1, 2, 3, or 4 independently selected R 8 groups.

11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 8 is independently selected from halo, CN, C 1-6 alkyl, Cy 2 , OR a2 , C(O)NR c2 R d2 , and NR c2 R d2 ; wherein said C 1-6 alkyl is optionally substituted with 1, 2, 3, or 4 independently selected R g groups.

12. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R a2 , R c2 and R d2 is independently selected from H, C 1-6 alkyl, and C 1-4 haloalkyl; wherein said C 1-6 alkyl and C 1-4 haloalkyl are each optionally substituted with 1 or 2 independently selected R g groups; and each R b2 is independently selected from C 1-6 alkyl and C 1-4 haloalkyl; wherein said C 1-6 alkyl and C 1-4 haloalkyl are each optionally substituted with 1 or 2 independently selected R g groups.

13. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R g is independently selected from OH, CN, halo, C 1-6 alkoxy, C 1-6 haloalkoxy, amino, C 1-6 alkylamino, and di(C 1-6 alkyl)amino.

14. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Z is —CH 2 —NH 2 .

15. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R a3 , R c3 and R d3 are each independently selected from H, methyl, ethyl, isopropyl, and Cy 3 ; R b3 is selected from methyl, ethyl, isopropyl, and Cy 3 ; and each Cy 3 is independently selected from cyclopropyl, cyclobutyl, cyclopentyl, morpholinyl, phenyl, pyrazolyl, furanyl, thienyl, isooxazolyl, and oxazolyl, each of which is optionally substituted by 1 or 2 groups independently selected from halo, OH, CN, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, amino, C 1-3 alkylamine, and di(C 1-3 alkyl)amino.

16. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is H, halo, CN, C 1-6 alkyl, C 1-4 haloalkyl, OR a1 , C(O)R b1 , C(O)NR c1 R d1 , OC(O)R b1 , OC(O)NR c1 R d1 , NR c1 R d1 , NR c1 C(O)R b1 , NR c1 S(O) 2 R b1 , S(O) 2 R b1 , or S(O) 2 NR c1 R d1 ; wherein said C 1-6 alkyl and C 1-4 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 11 groups.

17. The compound of claim 1 , selected from:

1-{2-[5-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-3-yl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{2-[6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2-yl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{2-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2-yl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{2-[2-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-4-yl]-2,3-dihydro-1H-inden-2-yl}methanamine;

N-({2-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2-yl]-2,3-dihydro-1H-inden-2-yl}methyl)acetamide;

N-({6-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridin-6-yl}methyl)acetamide;

1-{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanol;

N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)acetamide;

2-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)propanamide;

N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)cyclopropanecarboxamide;

4-{3-[2-(Fluoromethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-7H-pyrrolo[2,3-d]pyrimidine;

4-{3-[2-(Difluoromethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-7H-pyrrolo[2,3-d]pyrimidine;

N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl)}methyl)methanesulfonamide;

Methyl ({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)carbamate;

N,N-Dimethyl-1-{2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

N-Methyl-1-{2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

4-{3-[2-(Methoxymethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-7H-pyrrolo[2,3-d]pyrimidine;

N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)cyclobutanecarboxamide;

N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)cyclopentanecarboxamide;

N-((((2-3-(7H-Pyrrolo[2-3-d]pyrimidin-4-yl)phenyl)-2,3-dihydro-1H-inden-2-yl)methyl)thiophene-2-carboxamide;

1-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)-1H-pyrazole-3-carboxamide;

4-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)-1,3-oxazole-5-carboxamide;

N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)isoxazole-5-carboxamide;

1-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)-1H-pyrazole-5-carboxamide;

1-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)-1H-pyrazole-4-carboxamide;

N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)-2-furamide;

N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)morpholine-4-carboxamide;

{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}acetonitrile;

2-{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}ethanamine;

2-Methyl-N-(2-{2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}ethyl)propanamide;

N-(2-{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}ethyl)cyclopropanecarboxamide;

N-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclopropanamine;

N-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanamine;

N-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)-3,3-difluorocyclobutanamine;

(2R)-1-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)pyrrolidine-2-carboxamide;

(3S)-1-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)pyrrolidine-3-carboxamide;

(3S)-1-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)pyrrolidine-3-carbonitrile;

(2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(azetidin-1-ylmethyl)-2,3-dihydro-1H-inden-2-yl)methanamine;

(2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-((3-fluoroazetidin-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)methanamine;

1-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)azetidin-3-ol;

2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]indane-5-carbonitrile;

N-({5-Cyano-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)cyclopropanecarboxamide;

(3S)-1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}pyrrolidine-3-carbonitrile;

1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}-N,N-dimethylpyrrolidin-3-amine;

1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}-N-methylpyrrolidin-3-amine;

1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}pyrrolidin-3-ol;

1-(1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}pyrrolidin-3-yl)ethanol;

1-{5-(3-Fluoroazetidin-1-yl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}azetidin-3-ol;

1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}piperidin-3-ol;

1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}piperidine-4-carbonitrile;

N-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}tetrahydro-2H-pyran-4-amine;

1-{5-Pyrrolidin-1-yl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{5-Piperidin-1-yl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{5-Morpholin-4-yl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}piperidin-4-ol;

2-(Aminomethyl)-N-(2-methoxyethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]indan-5-amine;

2-(Aminomethyl)-N-(3-methoxypropyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]indan-5-amine;

2-(Aminomethyl)-N-[1-(methoxymethyl)cyclopropyl]-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]indan-5-amine;

1-{5-Phenyl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{5-(2-Fluorophenyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{5-(3-Fluorophenyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{5-(4-Fluorophenyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

4-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}-N,N-dimethylaniline;

1-{5-Imidazo[1,2-a]pyridin-6-yl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{5-(3-Methyl-3H-imidazo[4,5-b]pyridin-6-yl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{5-(6-Pyrrolidin-1-ylpyridin-3-yl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{5-(1-Ethyl-1H-imidazol-4-yl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

(2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(pyridin-3-yl)-2,3-dihydro-1H-inden-2-yl)methanamine;

(2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(pyridin-4-yl)-2,3-dihydro-1H-inden-2-yl)methanamine;

4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-butyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine;

4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine;

4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine;

4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine;

4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine;

4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine;

4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine;

1-{2-[3-(6-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine;

4-{2-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]pyridin-4-yl}-N-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; and

4-{2-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]pyridin-4-yl}-N-[3-(morpholin-4-ylmethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine;

or a pharmaceutically acceptable salt thereof.

18. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

19. The compound of claim 1 , having Formula IVa:

or a pharmaceutically acceptable salt thereof.

20. The compound of claim 1 , having Formula IVb:

or a pharmaceutically acceptable salt thereof.

21. The compound of claim 11 , having Formula IVc:

or a pharmaceutically acceptable salt thereof.

22. The compound of claim 1 , having Formula IVd:

or a pharmaceutically acceptable salt thereof.

23. The compound of claim 1 , having Formula IVe:

or a pharmaceutically acceptable salt thereof.

24. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is H, halo, CN, C 1-4 alkyl, or C 1-4 haloalkyl.

25. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is H or methyl.

26. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is H.

27. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 7 is independently selected from halo, C 1-6 alkyl, C 1-4 haloalkyl, CN, Cy, —C 1-4 alkylene-Cy, OR a , C(O)R b , C(O)NR c R d , C(O)OR a , OC(O)R b , OC(O)NR c R d , NR c R d , NR c OR d , NR c C(O)R b , NR c C(O)OR b , NR c C(O)NR c R d , NR c S(O) 2 R b , NR c S(O) 2 NR c R d , S(O) 2 R b , and S(O) 2 NR c R d ; wherein said C 1-6 alkyl and C 1-4 haloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R 8 groups.

28. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 7 is independently selected from halo, C 1-6 alkyl, C 1-4 haloalkyl, CN, Cy, —C 1-4 alkylene-Cy, OR a , C(O)R b , C(O)NR c R d , NR c R d , NR c C(O)R b , NR c S(O) 2 R b , S(O) 2 R b , and S(O) 2 NR c R d ; wherein said C 1-6 alkyl and C 1-4 haloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R 8 groups.

29. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 7 is independently selected from C 1-6 alkyl, CN, OH, NR c R d , Cy, and —C 1-4 alkylene-Cy; wherein said C 1-6 alkyl is optionally substituted with 1, 2, 3, or 4 independently selected R 8 groups.

30. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 8 is independently selected from halo, CN, C 1-6 alkyl, C 1-4 haloalkyl, Cy 2 , —C 1-4 alkylene-Cy 2 , OR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , NR c2 R d2 NR c2 OR d2 NR c2 C(O)R b2 , NR c2 C(O)OR b2 , NR c2 C(O)NR c2 R d2 ,NR c2 S(O) 2 R b2 . NR c2 S(O) 2 NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 NR c2 R d2 ; wherein said C 1-6 alkyl and C 1-4 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R g groups.

31. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 8 is independently selected from halo, CN, C 1-6 alkyl, C 1-4 haloalkyl, Cy 2 , —C 1-4 alkylene-Cy 2 , OR a2 C(O)R b2 , C(O)NR c2 R d2 , NR c2 R d2 , NR c2 C(O)R b2 , NR c2 S(O) 2 R b2 , S(O) 2 R b2 , and S(O) 2 NR c2 R d2 ; wherein said C 1-6 alkyl and C 1-4 haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R g groups.

32. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Z is C 1-4 alkyl, —CH 2 F, —CHF 2 , —CH 2 —Z 1 , —CH 2 —CH 2 —Z 1 , or —CH 2 —CH 2 —CH 2 —Z 1 .

33. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Z is —CH 2 F, —CHF 2 , —CH 2 —Z 1 , or —CH 2 —CH 2 —Z 1 .

34. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Z 1 is CN, OR a3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)OR b3 , or NR c3 S(O) 2 R b3 .

35. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Z 1 is NR c3 R d3 .

36. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R a3 , R c3 and R d3 are each independently selected from H, C 1-6 alkyl, and Cy 3 ; and each Cy 3 is independently 3-7 membered cycloalkyl, phenyl, 5-6 membered heteroaryl, or 4-6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 groups independently selected from halo, OH, CN, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, amino, C 1-3 alkylamine, and di(C 1-3 alkyl)amino; R b3 is selected from C 1-6 alkyl, and Cy 3 ; and each Cy 3 is independently selected from 3-7 membered cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 groups independently selected from halo, OH, CN, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1 - 3 haloalkoxy, amino, C i-3 alkylamine, and di(C 1-3 alkyl)amino.

37. A compound which is selected from:

1-{2-[4-(5-Methoxy-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl]-2,3-dihydro-1H-inden-2-yl}methanamine;

1-{2-[4-(1H-Pyrazolo[3,4-b]pyridin-4-yl)pyridin-2-yl]-2,3-dihydro-1H-inden-2-yl}methanamine;

3-(Aminomethyl)-3-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]indan-1-ol;

1-{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1,2,3,4-tetrahydronaphthalen-2-yl}methanamine;

1-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2(1H)-one;

1-{6-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridin-6-yl}methanamine;

1-{6-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-6-yl}methanamine; and

1-{2-[6-Chloro-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2-yl]-2,3-dihydro-1H-inden-2-yl}methanamine;

or a pharmaceutically acceptable salt thereof.