Treatment of pulmonary arterial hypertension with mesenchymal stem cells
The application is directed to a method for treating or preventing vasculopathy comprising administrating to a subject in need thereof a pharmaceutical composition comprising mesenchymal precursor cells (MPCs) and a prostacyclin. Also provided a method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.
1. A pharmaceutical composition comprising treprostinil or a pharmaceutically acceptable salt or ester thereof, a composition comprising a mesenchymal stem cell (MSC) or a part of a culture medium that has been in contact with the MSC and contains one or more components of the MSC, and a pharmaceutically acceptable carrier, wherein the MSC has been pre-treated ex vivo with treprostinil or a pharmaceutically acceptable salt or ester thereof during expansion of the MSC.
2. The composition of claim 1 , further comprising an endothelial progenitor cell (EPC).
3. The composition of claim 1 , wherein the pharmaceutical composition does not comprise an endothelial progenitor cell.