IP Library › Granted Patent US 10,076,508
Granted Patent B2
US 10,076,508 · App. 15/227,864 · Granted Sep 18, 2018

Pharmaceutical compositions for inhibiting antibiotic-resistant microorganisms and uses thereof

Inventors: Chiu-Hung Chen (Kaohsiung, TW); Yeh Chen (Kaohsiung, TW)
Assignee: Peptide Cham Biotech Co., Ltd.
A61K31/27
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Quick Facts
Patent No.
US 10,076,508
App. No.
15/227,864
Granted
Sep 18, 2018
Kind
B2
Abstract

This invention provides an antibiotic drug for inhibiting drug-resistant microorganisms. The antibiotic drug comprises Fmoc-Ala-OPfp, and not only has non-cytotoxic for normal human cell but also can inhibit drug-resistant microorganisms.

Claims (3)

1. A method for inhibiting Staphylococcus aureus , comprising contacting N-(9-fluorenylmethoxycarbonyl)-L-alanine pentafluorophenyl (Fmoc-Ala-OPfp) with Staphylococcus aureus , wherein N-(9-fluorenylmethoxycarbonyl)-L-alanine pentafluorophenyl has a structure shown as formula I:

2. The method of claim 1 , wherein an effective concentration of N-(9-fluorenylmethoxycarbonyl)-L-alanine pentafluorophenyl is 2.5-100 μM.

3. The method of claim 1 , wherein an effective concentration of N-(9-fluorenylmethoxycarbonyl)-L-alanine pentafluorophenyl is 2.5 μM.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2016
From: CHEN, CHIU-HUNG; CHEN, YEH
To: PEPTIDE CHAM BIOTECH CO., LTD.
Reel/Frame 039766/0875 →
Continuity (2)
Provisional Application 62200516 · Aug 3, 2015
Related Publication 20170035723A1 · Feb 9, 2017