Bisamide derivative of dicarboxylic acid as an agent for stimulating tissue regeneration and recovery of diminished tissue function
The invention relates to the field of medicine and concerns an agent that stimulates tissue regeneration and the recovery of diminished tissue and organ function. A medicinal agent for the treatment and/or prophylaxis of a pathological condition selected from the group including metabolic syndrome, impaired glucose tolerance, hepatitis, particularly chronic hepatitis and toxic hepatitis, idiopathic pulmonary fibrosis (IPF), emphysema of the lungs, chronic obstructive pulmonary disease (COPD) and cachexia, particularly as a result of impaired glucose tolerance, pulmonary fibrosis, chronic obstructive pulmonary disease, cancer and other diseases, is proposed in the form of an agent based on Treamide. The latter is a bisamide derivative of dicarboxylic acid of formula (I) or a pharmaceutically acceptable salt thereof.
1. A pharmaceutical composition, comprising an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
2. A method for regenerating a tissue, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof,
wherein the tissue is selected from the group consisting of a pancreatic tissue, a liver tissue, a lung tissue, a spermatogenic tissue, a testicular tissue, and a prostate tissue.
3. A method for normalizing a reduced male fertility, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof,
wherein the male fertility has been reduced in the subject due to a pathological condition selected from the group consisting of hypogonadism, asthenospermia, correlative testicular failure, and testicular failure.
4. A method for recovery of sperm motility, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof,
wherein the sperm motility has been reduced in the subject due to a pathological condition selected from the group consisting of hypogonadism, asthenospermia, correlative testicular failure, and testicular failure.
5. A method for reducing a blood glucose level, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof.
6. The method of claim 5 , wherein the blood glucose has been elevated in the subject due to a pathological condition.
7. The method of claim 6 , wherein the pathological condition is metabolic syndrome or glucose tolerance failure.