Systems and methods for treating autonomic instability and medical conditions associated therewith

1. A closed-loop therapy delivery system for treating autonomic instability or a medical condition associated therewith in a subject, the therapy delivery system comprising:

a sensing component configured to detect at least one physiological parameter associated with autonomic instability or the medical condition associated therewith;

a delivery component configured for implantation on or about an autonomic nervous tissue target or a spinal nervous tissue target; and

a controller configured to automatically coordinate operation of the sensing and delivery components;

wherein the controller is programmed to deliver, to the delivery component, an electrical signal that substantially increases sympathetic activity at the autonomic nervous tissue target or a spinal nervous tissue target to effectively treat the autonomic instability or the medical condition associated therewith.

2. The system of claim 1 , wherein the controller is programmed to deliver an electrical signal that substantially blocks activity at the autonomic nervous tissue target or a spinal nervous tissue target.

3. The system of claim 2 , wherein the controller is programmed to deliver an electrical signal having a frequency of about 10,000 Hz to about 25,000 Hz.

4. The system of claim 1 , wherein the at least one physiological parameter includes a chemical moiety or an electrical activity.

5. The system of claim 1 , wherein the autonomic nervous tissue target is a ganglion of the sympathetic nervous system (SNS).

6. The system of claim 5 , wherein the ganglion of the SNS is a cervical ganglion, a cervicothoracic ganglion, or a thoracic ganglion.

7. The system of claim 6 , wherein the cervical ganglion is an upper, middle, or lower cervical ganglion.

8. The system of claim 1 , wherein the spinal nervous tissue target is one of a cervical spinal cord segment, a thoracic spinal cord segment, a lumbar spinal cord segment, a sacral spinal cord segment, or spinal nervous tissue associated therewith.

9. A method for treating autonomic instability or a medical condition associated therewith in a subject, the method comprising the steps of:

placing a therapy delivery device into electrical communication with a ganglion of the sympathetic nervous system or a spinal nervous tissue target associated with autonomic instability or the medical condition associated therewith; and

activating the therapy delivery device to deliver an electrical signal to the ganglion of the sympathetic nervous system or the spinal nervous tissue target that substantially increases sympathetic activity in the ganglion of the sympathetic nervous system or the spinal nervous tissue target to effectively treat autonomic instability or the medical condition associated therewith in the subject.

10. The method of claim 9 , further comprising the steps of:

sensing at least one physiological parameter associated with autonomic instability or the medical condition associated therewith;

generating a sensor signal based on the at least one physiological parameter; and

activating the therapy delivery device to adjust application of the electrical signal to the ganglion of the sympathetic nervous system or the spinal nervous tissue target in response to the sensor signal to treat autonomic instability or the medical condition associated therewith.

11. The method of claim 10 , wherein the at least one physiological parameter includes a chemical moiety or an electrical activity.

12. The method of claim 9 , wherein the electrical signal has a frequency of about 10,000 Hz to about 25,000 Hz.

13. The method of claim 9 , wherein the ganglion of the sympathetic nervous system is a cervical ganglion, a cervicothoracic ganglion, or a thoracic ganglion.

14. The method of claim 13 , wherein the cervical ganglion is an upper, middle, or lower cervical ganglion.

15. The method of claim 9 , wherein the spinal nervous tissue target is one of a cervical spinal cord segment, a thoracic spinal cord segment, a lumbar spinal cord segment, a sacral spinal cord segment, or spinal nervous tissue associated therewith.

16. The method of claim 9 , wherein the medical condition associated with autonomic instability is a neurological condition.