Methods and compositions for reducing ocular discomfort
The invention relates to compositions and devices which include an osmolytic agent, in particular a betaine or carnitine compound, for reducing ocular discomfort associated with various diseases or conditions, in particular diseases or conditions associated with high tear film tonicity. The invention also relates to methods of treating or preventing various diseases or conditions using compositions and devices of the invention.
1. A contact lens, comprising:
i) a mixture of osmolytic agents, comprising:
a) between 5 and 20 mM of one or more carnitine compounds; and
b) between 5 and 20 mM of one or more betaine compounds; and
ii) a diffusion attenuator;
wherein the contact lens the mixture of osmolytic agents to be desorbed from the contact lens into the eye during wear to reduce ocular discomfort.
2. The contact lens of claim 1 , wherein the betaine compound has a molecular weight of about 600 Da or less.
3. The contact lens of claim 2 , wherein the betaine compound has a molecular weight of about 250 Da less.
4. The contact lens of claim 1 , wherein the betaine compound is selected from the group consisting of trimethylglycine, proline betaine, betaine hydrochloride, beta-alanine betaine, hydroxyproline betaine, cocamidopropylbetaine, carbethoxymethyltrimethylammonium hydroxide and analogs thereof.
5. The contact lens of claim 1 , wherein the betaine compound is selected from the group consisting of trimethylglycine, praline betaine, betaine hydrochloride, beta-alanine betaine and hydroxyproline betaine.
6. The contact lens of claim 1 , wherein the carnitine compound is selected from the group consisting of L-carnitine, alkanoyl L-carnitines including those selected from the group consisting of acetyl, propionyl, isovaleryl, butyryl, and isobutyryl L-carnitine and their pharmaceutically acceptable salts.
7. The contact lens of claim 6 , wherein the carntine compound is L-carnitine.
8. The contact lens of claim 1 , wherein the contact lens is a single use contact lens.
9. The contact lens of claim 1 , wherein the device permits a therapeutically effective amount of the osmolytic agent to be desorbed over about a 12 hour period.
10. The contact lens of claim 1 , wherein the diffusion attenuator is vitamin E.
11. The contact lens of claim 1 , wherein the concentration of the one or more betaine compounds present in the contact lens is 20 mM.
12. The contact lens of claim 11 , wherein the betaine compound is selected from the group consisting of trimethylglycine, proline betaine, betaine hydrochloride, beta-alanine betaine, hydroxyproline betaine, cocamidopropylbetaine, carbethoxymethyltrimethylammonium hydroxide and analogs thereof.
13. The contact lens of claim 12 , wherein the betaine compound is selected from the group consisting of trimethylglycine, praline betaine, betaine hydrochloride, beta-alanine betaine and hydroxyproline betaine.
14. The contact lens of claim 13 , wherein the concentration of the one or more betaine compounds present in the contact lens is 10 mM.
15. The contact lens of claim 1 , wherein the concentration of the one or more carnitine compounds present in the contact lens is 20 mM.
16. The contact lens of claim 15 , wherein the carnitine compound is selected from the group consisting of L-carnitine, alkanoyl L-carnitines including those selected from the group consisting of acetyl, propionyl, isovaleryl, butyryl, and isobutyryl L-carnitine and their pharmaceutically acceptable salts.
17. The contact lens of claim 16 , wherein the carntine compound is L-carnitine.
18. The contact lens of claim 17 , wherein the concentration of the one or more carnitine compounds present in the contact lens is 10 mM.