Methods of treatment using stem cell mobilizers
The present invention relates to the field of stem cells. In one aspect, the present invention provides methods of treating a subject with acute liver injury comprising administering to the subject a therapeutically effective amount of at least one stem cell mobilizer. In particular embodiments, the subject is treated with plerixafor and granulocyte colony-stimulating factor (G-CSF).
1. A method for treating a subject with acute liver injury comprising administering to the subject a therapeutically effective amount of plerixafor and granulocyte colony stimulating factor (G-CSF) to mobilize CD34+ stem cells from the bone marrow into the peripheral blood.
2. The method of claim 1 , wherein plerixafor is administered in a range of about 200 μg to about 3 mg per kg of body weight.
3. The method of claim 2 , wherein plerixafor is administered in a dose of about 2 mg/kg of body weight.
4. The method of claim 1 , wherein G-CSF is administered in a range of about 10 μg to about 1 mg/kg of body weight.
5. The method of claim 4 , wherein G-CSF is administered in a dose of about 300 μg/kg of body weight.
6. The method of claim 1 , wherein the acute liver injury comprises acute liver failure.
7. The method of claim 1 , wherein the acute liver injury comprises post-surgical resection.
8. A method for treating a subject with acute liver failure comprising administering to the subject a therapeutically effective amount of plerixafor and granulocyte colony stimulating factor (G-CSF) to mobilize CD34+ stem cells from the bone marrow into the peripheral blood.
9. The method of claim 8 , wherein plerixafor is administered in a range of about 200 μg to about 3 mg per kg of body weight.
10. The method of claim 9 , wherein plerixafor is administered in a dose of about 2 mg/kg of body weight.
11. The method of claim 8 , wherein G-CSF is administered in a range of about 10 μg to about 1 mg/kg of body weight.
12. The method of claim 11 , wherein G-CSF is administered in a dose of about 300 μg/kg of body weight.