System and method for detecting minimum hematocrit with irradiation receivers during extracorporeal photopheresis
An irradiation device for photopheresis, comprising an exposure chamber configured to receive an illumination container holding a target cell suspension, an irradiation transmitter configured to irradiate the illumination container and target cell suspension, an irradiation receiver configured to detect absorption of radiation from the irradiation transmitter, and a processing circuit coupled to the irradiation receiver and configured to determine whether a hematocrit of the target cell suspension exceeds a predetermined threshold hematocrit and to treat the target cell suspension with a treatment dosage of radiation if the predetermined threshold is exceeded.
1. An irradiation device for photopheresis, comprising:
an exposure chamber configured to receive an Hum nation container holding a target cell suspension;
an irradiation transmitter configured to irradiate the illumination container and target cell suspension;
an irradiation receiver configured to detect radiation from the irradiation transmitter; and
a processing circuit coupled to the irradiation receiver and configured to detect radiation absorption and to determine whether a hematocrit of the target cell suspension exceeds a predetermined threshold hematocrit and to treat the target cell suspension with a treatment dosage of radiation if the predetermined threshold is exceeded.
2. The irradiation device of claim 1 , wherein the irradiation device is configured to elicit a response action if the hematocrit of the target cell suspension does not exceed the predetermined threshold hematocrit, the response action comprising at least one of terminating the photopheresis procedure, generating an error notification; and processing additional cell suspensions to increase hematocrit.
3. The irradiation device of claim 1 , wherein the processing circuit is configured to use the irradiation transmitter and irradiation receiver to detect the hematocrit of the target cell suspension and to control the irradiation transmitter to treat the target cell suspension with the treatment dosage of radiation.
4. The irradiation device of claim 3 , wherein the processing circuit is configured to use signals from the irradiation receiver to control a magnitude of the treatment dosage of radiation.
5. The irradiation device of claim 1 , wherein the irradiation device is part of an online or offline system and wherein the irradiation transmitter transmits UV-A light and the irradiation receiver receives UV-A light.
6. The irradiation device of claim 1 , wherein the target cells comprise mononuclear cells and the target cell suspension comprises a photoactivation agent 8-methoxypsoralen.
7. The irradiation device of claim 1 , wherein the irradiation transmitter is configured to transmit more than 10 times as much radiation than is actually absorbed by the target cells within the suspension.
8. The irradiation device of claim 1 , wherein the irradiation receiver is tuned to exclude frequencies of irradiation other than the UV frequency emitted from the irradiation transmitter of the irradiation device and decrease ambient light interference.
9. The irradiation device of claim 1 , wherein the irradiation receiver is disposed within the exposure chamber.
10. A method for detecting hematocrit during an extracorporeal photopheresis procedure, comprising the steps of:
providing an exposure chamber configured to receive an illumination container holding a target cell suspension containing a selected amount of a photoactivation agent;
providing an irradiation device having an irradiation transmitter configured to irradiate contents within the illumination container, wherein the irradiation device contains at least one irradiation receiver;
irradiating the target cell suspension with the irradiation device while detecting hematocrit by analyzing amount of radiation detected by the irradiation receivers; and
providing a response action when a hematocrit below a minimum acceptable hematocrit is detected.
11. The method of claim 10 , wherein the target cell suspension comprises mononuclear cells and the photoactivation agent comprises 8-methoxypsoralen.
12. The method of claim 10 , wherein the irradiation transmitter is configured to transmit more than 10 times as much radiation than is actually absorbed by target cells within the suspension.
13. The method of claim 10 , wherein the irradiation device is configured to elicit a response action if the hematocrit of the target cell suspension does not exceed the predetermined threshold hematocrit, the response action comprising at least one of terminating the photopheresis procedure, generating an error notification; and processing additional cell suspensions to increase hematocrit.
14. The method of claim 10 , wherein the irradiation device is part of an online system and wherein the irradiation transmitter transmits UV-A light and the irradiation receiver receives UV-A light.
15. The method of claim 10 , wherein the irradiation receiver is tuned to exclude frequencies of radiation other than the UV frequency emitted from the irradiation transmitter of the irradiation device and decrease ambient light interference.
16. The method of claim 10 , wherein the irradiation receiver is disposed within the exposure chamber.