System, method and computer-accessible medium for secure and compressed transmission of genomic data
An exemplary system, method and computer-accessible medium can be provided for generating an encrypted reference-based secure-compression of randomly located short sequence reads from a genome(s), which can, for example, including obtaining information related to the randomly located short sequence reads, obtaining second information related to a plurality of reference sequences for the genome(s), generating third information related to a set of edit calls containing location information based on the first and second information using a base-calling procedure and an alignment procedure, and generating the encrypted reference-based secure-compression of the first information based on the third information. The exemplary system, method and computer-accessible medium can facilitate the exemplary chemistry box to generate analog information to be locally and physically separated from informatics box interpreting digital data.
1. A non-transitory computer-accessible medium having stored thereon computer-executable instructions for generating at least one compressed genetic sequence, wherein, when a computer arrangement executes the instructions, the computer arrangement is configured to perform procedures comprising:
(a) obtaining at least one reference sequence;
(b) obtaining a particular sequence read for at least one genetic sequence from a sequence platform;
(c) comparing the particular sequence read to the at least one reference sequence;
(d) storing the particular sequence read only if the particular sequence read does not match the at least one reference sequence; and
(e) generating the at least one compressed genetic sequence by repeating procedures (b)-(d) for further sequence reads which are different from the particular sequence read.
2. The computer-accessible medium of claim 1 , wherein the computer arrangement is further configured to store location information for the particular sequence read only if the particular sequence read does not match the at least one reference sequence.
3. The computer-accessible medium of claim 2 , wherein the computer arrangement is further configured to encrypt the location information.
4. The computer-accessible medium of claim 3 , wherein the computer arrangement is configured to encrypt the location information using a public-key crypto procedure.
5. A method for generating at least one compressed genetic sequence, comprising:
(a) obtaining at least one reference sequence;
(b) obtaining a particular sequence read for at least one genetic sequence from a sequence platform;
(c) comparing the particular sequence read to the at least one reference sequence;
(d) storing the particular sequence read only if the particular sequence read does not match the at least one reference sequence; and
(e) using a computer hardware arrangement, generating the at least one compressed genetic sequence by repeating procedures (b)-(d) for further sequence reads which are different from the particular sequence read.
6. The method of claim 5 , further comprising storing location Information for the particular sequence read only if the particular sequence read does not match the at least one reference sequence.
7. The method of claim 6 , wherein further comprising encrypting the location information.
8. The method of claim 7 , wherein the encryption of the location information is performed using a public-key crypto procedure.
9. A system for generating at least one compressed genetic sequence, comprising:
a computer hardware arrangement configured to:
(a) obtaining at least one reference sequence;
(b) obtaining a particular sequence read for at least one genetic sequence from a sequence platform;
(c) comparing the particular sequence read to the at least one reference sequence;
(d) storing the particular sequence read only if the particular sequence read does not match the at least one reference sequence; and
(e) generating the at least one compressed genetic sequence by repeating procedures (b)-(d) for further sequence reads which are different from the particular sequence read.
10. The system of claim 9 , wherein the computer hardware arrangement is further configured to store location information for the particular sequence read only if the particular sequence read does not match the at least one reference sequence.
11. The system of claim 10 , wherein the computer hardware arrangement is further configured to encrypt the location information.
12. The system of claim 11 , wherein the computer hardware arrangement is configured to encrypt the location information using a public-key crypto procedure.