IP Library › Granted Patent US 10,117,919
Granted Patent B2
US 10,117,919 · App. 15/810,924 · Granted Nov 6, 2018

Methods and materials for generating CD8

Inventors: Keith L. Knutson (Jacksonville, FL); Andrea M. Henle (Cambridge, MA)
Assignee: Mayo Foundation for Medical Education and Research
A61K39/0011A61K38/193A61K38/208A61K38/2013A61K45/06C07K14/71H05K999/99A61K2039/55566
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Quick Facts
Patent No.
US 10,117,919
App. No.
15/810,924
Granted
Nov 6, 2018
Kind
B2
Abstract

This document provides methods and materials for generating CD8 − T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide. For example, methods and materials for using a polypeptide consisting of an SLAFLPESFD amino acid sequence in vivo or in vitro to generate CD8 + T cells having the ability to recognize and lyse cancer cells expressing a HER2/neu polypeptide are provided.

Claims (4)

1. A composition comprising an immunogenically effective amount of a polypeptide and an adjuvant selected from the group consisting of a CpG oligonucleotide, monophosphoryl lipid A, and Montanide ISA-51, wherein the sequence of said polypeptide consists of the amino acid sequence set forth in SEQ ID NO:1.

2. The composition of claim 1 , wherein said adjuvant is said CpG oligonucleotide.

3. The composition of claim 1 , wherein said adjuvant is said monophosphoryl lipid A.

4. The composition of claim 1 , wherein said adjuvant is said Montanide ISA-51.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 8, 2018
From: KNUTSON, KEITH L.; HENLE, ANDREA M.
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 047087/0671 →
CONFIRMATORY LICENSE Recorded Dec 15, 2017
From: MAYO CLINIC ROCHESTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 044881/0776 →
Continuity (3)
Continuation 14379150
Provisional Application 61600480 · Feb 17, 2012
Related Publication 20180064797A1 · Mar 8, 2018