Conjugated lipomers and uses thereof

1. A conjugated lipomer of Formula (IV):

or salt thereof; wherein:

each instance of L 3 is independently:

each instance of R 8 is independently hydrogen; acyl; silyl; sulfonyl; an amino protecting group; substituted or unsubstituted alkyl; substituted or unsubstituted alkenyl; substituted or unsubstituted alkynyl; substituted or unsubstituted heteroalkyl; substituted or unsubstituted heteroalkenyl; substituted or unsubstituted heteroalkynyl; substituted or unsubstituted carbocyclyl; substituted or unsubstituted heterocyclyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; or

provided the conjugated lipomer contains two, three, or four groups of Formula (iii′);

each instance of R 3 is independently substituted or unsubstituted C 5-20 alkyl; substituted or unsubstituted alkenyl; substituted or unsubstituted alkynyl; substituted or unsubstituted heteroalkenyl; substituted or unsubstituted heteroalkynyl; substituted or unsubstituted carbocyclyl; substituted or unsubstituted heterocyclyl; substituted or unsubstituted heteroaryl; or a hydrophilic polymer;

each instance of R 4 is independently hydrogen, acyl; silyl; a hydroxyl protecting group; substituted or unsubstituted alkyl; substituted or unsubstituted alkenyl; substituted or unsubstituted alkynyl; substituted or unsubstituted heteroalkyl; substituted or unsubstituted heteroalkenyl; substituted or unsubstituted heteroalkynyl; substituted or unsubstituted carbocyclyl; substituted or unsubstituted heterocyclyl; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl;

each instance of m and p is 1;

q is 2; and

the dashed curved line, together with G and Y, is a covalent bond.

2. The conjugated lipomer of claim 1 , wherein each instance of R 8 is independently hydrogen or a group of Formula (iii′).

3. The conjugated lipomer of claim 1 , wherein each instance of R 3 is independently substituted or unsubstituted C 5-20 alkyl or a hydrophilic polymer.

4. The conjugated lipomer of claim 1 , wherein at least one instance of R 3 is substituted or unsubstituted C 5-20 alkyl.

5. The conjugated lipomer of claim 1 , wherein the lipomer is of Formula (V):

or salt thereof.

6. The conjugated lipomer of claim 1 , wherein the conjugated lipomer is selected from the group consisting of:

and salts thereof.

7. A composition comprising one or more conjugated lipomers of claim 1 , and, optionally, an excipient.

8. The composition of claim 7 , wherein the composition is a pharmaceutical composition or a cosmetic composition.

9. The composition of claim 7 , wherein the composition further comprises an agent.

10. The composition of claim 9 , wherein the agent is an organic molecule, inorganic molecule, protein, peptide, polynucleotide, targeting agent, isotopically labeled chemical compound, vaccine, or immunological agent.

11. The composition of claim 10 , wherein the agent is a polynucleotide.

12. The composition of claim 7 , wherein the one or more conjugated lipomers are in the form of a particle.

13. The composition of claim 9 , wherein the agent is a polynucleotide that encodes a protein or peptide.

14. The composition of claim 11 , wherein the polynucleotide is DNA.

15. The composition of claim 11 , wherein the polynucleotide is RNA.

16. The composition of claim 15 , wherein the RNA is RNAi, dsRNA, siRNA, shRNA, miRNA, or antisense RNA.

17. A method of preparing a conjugated lipomer of claim 1 , the method comprising contacting a compound of Formula (III), or salt thereof, with an epoxide of Formula (xii):

wherein each instance of L 2 is independently:

provided that at least one R 8 group is hydrogen;

to provide the conjugated lipomer of claim 1 .