Production method of enzalutamide crystal form
The present invention aims to provided a novel production method of an enzalutamide crystal form in which wet crystals of enzalutamide are obtained in a step of crystallizing in the production process of the enzalutamide crystal form, and then 2-propanol which is solvated with enzalutamide and the B-type crystals are reduced. The present invention relates to a production method of an enzalutamide crystal form, which comprises a step of crystallizing for obtaining wet crystals of enzalutamide, and a step of drying the wet crystals, and comprises a step of washing using a mixed solvent of a good solvent and a poor solvent after the step of crystallizing.
1. A method of producing a crystal form of enzalutamide:
comprising a step of crysallizing for obtaining wet crystals of enzalutamide and a step of drying the wet crystals, wherein the method comprises a step of washing using a mixed solvent of a good solvent and a poor solvent after the step of crystallizing, wherein the good solvent is isopropyl acetate and the poor solvent is n-heptane.