Cleaning of biological fluid
The present invention relates to removal of protein bound deleterious substances from an extracorporeal biological fluid by changing the affinity of the substance to the protein. The invention relates to the use of displacer substances for removal of deleterious substances. The present invention also relate to a method of removal, a system, a cleaning fluid comprising the displacer substances for removal of deleterious substances.
1. A method of removing a deleterious substance bound to a protein in an extracorporeal biological fluid comprising:
a) introducing a displacer substance into the biological fluid under conditions in which the displacer substance displaces deleterious substance bound to the protein, thereby resulting in additional unbound deleterious substances in the biological fluid; and
b) removing unbound deleterious substance from the biological fluid,
wherein the displacer substance is a combination of sodium octanoate with one or both of sodium salicylate and sodium acetylsalicylate.
2. A method according to claim 1 , wherein the step a) and step b) are performed at a temperature of between 30 and 60 degrees Celsius.
3. A method according to claim 1 , wherein the step a) and step b) are performed at pH of between 5 and 8.
4. A method according to claim 1 , wherein the biological fluid is blood; blood plasma; or peritoneal fluid.
5. A method according to claim 1 , wherein the step b) is performed by any one or more of the methods comprising dialysis, electrodialysis or plasmapheres.