Monoclonal antibodies for treatment of cancer
View Patent ↗The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
1. A method of inhibiting growth of a cell expressing GT468 and/or being characterized by association of GT468 with its cell surface, comprising contacting the cell with an effective amount of an antibody that binds to a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO: 3-10 and 35-79, or a conjugate thereof.
2. A method of killing a cell expressing GT468 and/or being characterized by association of GT468 with its cell surface, comprising contacting the cell with an effective amount of an antibody that binds to a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO: 3-10 and 35-79, or a conjugate thereof.
3. A method of inhibiting metastatic spread of a cell expressing GT468 and/or being characterized by association of GT468 with its cell surface, comprising contacting the cell with an effective amount of an antibody that binds to a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO: 3-10 and 35-79, or a conjugate thereof.
4. A method of treating a disease or disorder involving cells expressing GT468 and/or being characterized by association of GT468 with their cell surface, comprising administering to a subject an antibody that binds to a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO: 3-10 and 35-79, or a conjugate thereof.
5. The method of claim 4 wherein the disease or disorder is cancer.
6. The method of claim 5 wherein the cancer is selected from the group consisting of breast cancer, lung cancer, gastric cancer, ovarian cancer and hepatocellular cancer.
7. The method of any one of claims 1 - 6 , wherein said antibody binds to GT468 having the amino acid sequence according to SEQ ID NO: 2.
8. The method of claim 7 wherein said antibody binds to the extracellular domain of a protein comprising the amino acid sequence of SEQ ID NO: 2.
9. The method of claim 7 , wherein said antibody is a monoclonal antibody, a chimeric antibody, a human or a humanized antibody, or an antigen-binding fragment of an antibody.
10. The method of claim 7 , wherein the antibody is selected from the group consisting of an IgG1, an IgG2, an IgG3, an IgG4, an IgM, an IgA1, an IgA2, a secretory IgA, an IgD, and an IgE antibody.
11. The method of claim 7 , wherein the antibody is selected from the group consisting of an IgG2a and IgG2b antibody.
12. The method of claim 7 , wherein the antibody conjugate comprises the antibody coupled to a therapeutic agent selected from a toxin, a radioisotope, a drug, or a cytotoxic agent.