IP Library › Granted Patent US 10,138,483
Granted Patent B2
US 10,138,483 · App. 15/425,007 · Granted Nov 27, 2018

Transferrin/transferrin receptor-mediated siRNA delivery

Inventors: Jon E. Chatterton (Fort Worth, TX); Abbot F. Clark (Arlington, TX)
Assignee: Arrowhead Pharmaceuticals, Inc.
C12N15/113A61K9/0048A61K31/7088A61K31/713A61K47/64A61K47/644A61K47/6849C12N15/87C12N2310/14C12N2310/141C12N2310/3513C12N2320/32
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Quick Facts
Patent No.
US 10,138,483
App. No.
15/425,007
Granted
Nov 27, 2018
Kind
B2
Abstract

The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a transferrin receptor (TfR). Therapeutic uses for the conjugates are also provided.

Claims (7)

1. A composition comprising an interfering RNA molecule-ligand conjugate, wherein the ligand comprises a peptide comprising a transferrin receptor (TfR) binding domain of transferrin (Tf) that is covalently linked to a protamine, wherein the protamine is covalently linked to the interfering RNA, and wherein the interfering RNA is able to mediate RNA interference in a cell.

2. The composition of claim 1 , wherein the ligand comprises the full length TfR binding domain of transferrin.

3. The composition of claim 1 , wherein the ligand comprises the transferrin C-lobe.

4. The composition of claim 2 , wherein the interfering RNA molecule is a siRNA, miRNA, or shRNA.

5. The composition of claim 3 , wherein the interfering RNA molecule is a siRNA, miRNA, or shRNA.

6. The composition of claim 4 , wherein the interfering RNA molecule is a siRNA.

7. The composition of claim 5 , wherein the interfering RNA molecule is a siRNA.

Assignments (4)
SECURITY INTEREST Recorded Aug 7, 2024
From: ARROWHEAD PHARMACEUTICALS, INC.
To: SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT
Reel/Frame 068510/0363 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 26, 2018
From: CHATTERTON, JON E.; CLARK, ABBOT F.
To: ALCON RESEARCH, LTD.
Reel/Frame 044734/0599 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 26, 2018
From: ALCON RESEARCH, LTD.
To: ARROWHEAD RESEARCH CORPORATION
Reel/Frame 044734/0614 →
CHANGE OF NAME Recorded Jan 26, 2018
From: ARROWHEAD RESEARCH CORPORATION
To: ARROWHEAD PHARMACEUTICALS, INC.
Reel/Frame 045167/0156 →
Continuity (6)
Continuation 14801161 · Jul 16, 2015
Continuation 13765216 · Feb 12, 2013
Division 13112635 · May 20, 2011
Continuation 12244027 · Oct 2, 2008
Provisional Application 60977272 · Oct 3, 2007
Related Publication 20170145415A1 · May 25, 2017
Cited By (2)
US 12,624,358 US 12,742,170