Polymer membranes for continuous analyte sensors
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
1. A device for continuous measurement of an analyte concentration, the device comprising:
a sensor configured to continuously measure a signal associated with an analyte concentration in a host; and
a membrane located over the sensing mechanism, wherein the membrane comprises a polyurethane and a hydrophilic portion;
wherein the device is configured to provide, at analyte concentrations of from about 40 mg/dL to about 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference from 6.8% to 9.6% over a sensor session extending over a period of 7 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood.
2. The device of claim 1 , wherein the membrane comprises an enzyme configured to react with the analyte.
3. The device of claim 1 , wherein the membrane comprises a copolymer comprising a fluorocarbon segment.
4. The device of claim 1 , wherein the membrane comprises a copolymer comprising a silicone segment.
5. The device of claim 1 , wherein the membrane comprises a polycarbonate segment.
6. The system of claim 1 , wherein the sensor has a sensor life, wherein the sensor life comprises the sensor session.
7. A system for continuous measurement of an analyte concentration, the system comprising:
a sensor comprising:
a sensing region configured to continuously produce sensor data associated with an analyte concentration in a host; and
a membrane located over the sensing region, wherein the membrane comprises a polyurethane and a hydrophilic portion;
a processor configured to process continuous sensor data; and
a user interface configured to display information associated with continuous sensor data;
wherein the sensor is configured to provide, at analyte concentrations of from about 40 mg/dL to about 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference from 6.8% to 9.6% over a sensor session extending over a period of 7 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood.
8. The system of claim 7 , wherein the membrane comprises an enzyme configured to react with the analyte.
9. The system of claim 7 , wherein the membrane comprises a copolymer comprising a fluorocarbon segment.
10. The system of claim 7 , wherein the membrane comprises a copolymer comprising a silicone segment.
11. The system of claim 7 , wherein the membrane comprises a polycarbonate segment.
12. The system of claim 7 , wherein the sensor has a sensor life, wherein the sensor life comprises the sensor session.