Systems and methods that use multi-modal imaging for enhanced resolution images
One aspect of the present disclosure relates to a system that can employ multi-modal imaging to provide an image with an enhanced resolution. In some instances, the multi-modal imaging can allow an operator to determine and control a tissue margin without the need for intra-operative tissue pathology. The system can include an imaging system that includes a gamma camera to detect a gamma image and an optical imaging modality to detect an optical image. The system can also include a display device to display an enhanced gamma image created based on a function of the optical image. The enhanced gamma image illustrates a characteristic of a disease in the field of view (e.g., a lymphatic pathway, a sentinel lymph node target, or a satellite disease state).
1. A method comprising:
receiving, by a system comprising a processor, a collimator-based optical image of a field of view related to a patient, a lens-based optical image of the field of view, and a gamma image of the field of view;
determining, by the system, a resolution corruption function for optical imaging based on the collimator-based optical image of the field of view and the lens-based optical image of the field of view;
approximating, by the system, a resolution corruption function for gamma imaging based on the resolution corruption function for optical imaging;
enhancing, by the system, a resolution of the gamma image of the field of view based on the resolution corruption function for gamma imaging.
2. The method of claim 1 , wherein the collimator-based optical image of the field of view is a low-resolution image and the lens-based optical image of the field of view is a high-resolution image.
3. The method of claim 1 , wherein the gamma image of the field of view is a low resolution image.
4. The method of claim 1 , wherein the resolution corruption function for gamma imaging is approximated as equal to the resolution corruption function for optical imaging.
5. The method of claim 1 , wherein the optical images are produced by an optical imaging modality and the gamma image is produced by a gamma imaging modality.
6. The method of claim 1 , wherein the collimator-based optical image and the lens-based optical image of the field of view are formed by splitting an optical beam at a beam splitter to permit collimator-based detection and lens-based detection.
7. A method comprising:
receiving a gamma image of a field of view of a patient;
receiving a first optical image of the field of view of the patient;
receiving a second optical image of the field of view of the patient;
creating, by a system comprising a processor, an enhanced gamma image of the field of view based on the first optical image and the second optical image;
displaying the enhanced gamma image to provide intraoperative guidance,
wherein the enhanced gamma image has a greater resolution than the gamma image.
8. The method of claim 7 , wherein the first optical image comprises a collimator-based optical image and the second optical image comprises a lens-based optical image.
9. The method of claim 8 , wherein the resolution of the gamma image is increased based on a difference between the collimator-based optical image and the lens-based optical image.
10. The method of claim 7 , wherein the enhanced gamma image illustrates a characteristic of a disease in the field of view that facilitates the intraoperative guidance.
11. A system comprising:
a gamma camera configured to receive a gamma image of a field of view of a patient,
an optical imaging modality configured to receive:
a first optical image of the field of view of the patient, and
a second optical image of the field of view of the patient;
a processor that creates an enhanced gamma image of the field of view based on the first optical image and the second optical image; and
a display device that displays the enhanced gamma image to provide intraoperative guidance,
wherein the enhanced gamma image has a greater resolution than the gamma image.
12. The system of claim 11 , wherein the first optical image comprises a collimator-based optical image and the second optical image comprises a lens-based optical image.
13. The system of claim 11 , wherein the resolution of the gamma image is increased based on a difference between the collimator-based optical image and the lens-based optical image.
14. The system of claim 11 , wherein the enhanced gamma image illustrates a characteristic of a disease in the field of view that facilitates the intraoperative guidance.