Orosoluble and/or effervescent compositions containing at least a salt of S-adenosyl methionine (SAMe)
View Patent ↗The present invention refers to pharmaceutical, dietary and/or nutraceutical orosoluble and/or effervescent compositions for oral use containing at least a salt of S-adenosyl methionine (SAMe), combined with physiologically acceptable excipients and optionally additional active ingredients. In particular the invention refers to compositions with high palatability formulated in tablet, capsule or granules. The present invention also refers to the use of at least a salt of SAMe combined with physiologically acceptable excipients and optionally further active ingredients for treating, human or veterinarian, neuropsychiatric, osteoarticular or hepatic diseases.
1. Method for obtaining the plasma peak of the S-adenosyl methionine ion within a period of time comprised between 1 and 2 hours characterized by administering a pharmaceutical, dietary and/or nutraceutical orosoluble tablet composition containing at least a salt of S-adenosyl methionine combined with physiologically acceptable excipients wherein said physiologically acceptable excipients comprise light magnesium oxide and at least one fat selected from the group consisting of stearic acid and hydrogenated vegetable oil wherein said tablet is configured for orosolubility.
2. Method according to claim 1 , for obtaining the plasma peak of the S-adenosyl methionine ion after about one and a half hours from intake of the composition.
3. A method of treatment of a disease, wherein said method comprises the step of administering an orosoluble tablet containing at least a salt of S-adenosyl methionine combined with physiologically acceptable excipients wherein said physiologically acceptable excipients comprise light magnesium oxide, and at least one fat selected from the group consisting of stearic acid and hydrogenated vegetable oil to treat a disease selected from the group consisting of neuropsychiatric, osteoarticular and hepatic diseases.
4. The method of claim 3 , wherein said step of treating a disease comprises treating a disease selected from the group consisting of depression syndromes, anxiety, dementia, alcoholic steatosis, acute hepatitis, chronic hepatitis, alcoholic cirrhosis, post-viral cirrhosis, intrahepatic cholestasis and degenerative skeletal-muscular diseases with mobility disorders.
5. A method of increasing the plasma concentration of the S-adenosyl methionine ion within a patient, wherein said method comprises the step of administering a pharmaceutical, dietary, and/or nutraceutical orosoluble tablet containing at least a salt of S-adenosyl methionine combined with physiologically acceptable excipients wherein said physiologically acceptable excipients comprise light magnesium oxide and at least one fat selected from the group consisting of stearic acid and hydrogenated vegetable oil.
6. The method of claim 5 , wherein said method produces a plasma concentration of s-adenosyl methionine at least 40% higher with respect to the base value within a period of time comprising between 1 and 2 hours.
7. The method of claim 5 wherein said method produces a plasma concentration of s-adenosyl methionine at least 50% higher with respect to the base value within a period of time comprising between 1 and 2 hours.
8. The method of claim 5 wherein said method produces a plasma concentration of s-adenosyl methionine at least about 48% higher with respect to the base value after about 1 and a half hours from intake.