Chemical compounds
The specification relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.
1. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is N-(2-((5-((1R,3R)-2-(2,2-difluoroethyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-4-methoxypyridin-2-yl)oxy)ethyl)-3-fluoropropan-1-amine, which compound has the following structure:
2. A pharmaceutical composition, which comprises the compound according to claim 1 , or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically-acceptable excipient.
3. A compound, wherein the compound is N-(2-((5-(1R,3R)-2-(2,2-difluoroethyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-4-methoxypyridin-2-yl)oxy)ethyl)-3-fluoropropan-1-amine.
4. A pharmaceutical composition, which comprises the compound according to claim 3 , in association with a pharmaceutically-acceptable excipient.
5. A pharmaceutically acceptable salt of N-(2-((5-((1R,3R)-2-(2,2-difluoroethyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-4-methoxypyridin-2-yl)oxy)ethyl)-3-fluoropropan-1-amine.
6. A pharmaceutical composition, which comprises the salt according to claim 5 , in association with a pharmaceutically-acceptable excipient.
7. A pharmaceutically acceptable salt, wherein the pharmaceutically acceptable salt is the 2-methoxybenzoate salt of N-(2-((5-((1R,3R)-2-(2,2-difluoroethyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-4-methoxypyridin-2-yl)oxy)ethyl)-3-fluoropropan-1-amine.
8. A pharmaceutical composition, which comprises the salt according to claim 7 , in association with a pharmaceutically-acceptable excipient.