Uses of indolinone compounds
Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.
1. A method for inducing apoptosis in a cell comprising a myeloblast produced in acute myeloid leukemia or a lymphocyte produced in diffuse large B cell lymphoma, comprising contacting the cell with an effective amount of a combination of:
venetoclax; and
a compound having a structure:
or a stereoisomer, a pharmaceutically acceptable salt, or solvate thereof.
2. The method of claim 1 , wherein the compound has a structure:
3. The method of claim 1 , wherein the compound has a structure:
4. The method of claim 1 , wherein the cell is a myeloblast produced in acute myeloid leukemia.
5. The method of claim 1 , wherein the cell is a lymphocyte produced in diffuse large B cell lymphoma.
6. A pharmaceutical composition, comprising:
venetoclax; and
a compound having a structure:
or a stereoisomer, a pharmaceutically acceptable salt, or solvate thereof.
7. The pharmaceutical composition of claim 6 , wherein the compound has a structure:
8. The pharmaceutical composition of claim 6 , wherein the compound has a structure: