IP Library › Granted Patent US 10,173,074
Granted Patent B2
US 10,173,074 · App. 14/437,064 · Granted Jan 8, 2019

Cancer stem cell vaccination and treatment

Inventor: Qiao Li (Ann Arbor, MI)
Assignee: The Regents of The University of Michigan
A61N5/1001A61K39/0011A61K45/06A61K51/00A61N5/1077A61K2039/5154A61K2039/5158A61N2005/1024A61N2005/1098
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Quick Facts
Patent No.
US 10,173,074
App. No.
14/437,064
Granted
Jan 8, 2019
Kind
B2
Abstract

The present invention relates to methods, systems, and compositions for treating and preventing cancer in a subject with the combination of radiation therapy and antigen presenting cells that have been exposed cancer stem cells or a portion thereof. In certain embodiments, the antigen presenting cells are dendritic cells that have been pulsed with ALDH high cancer stem cells.

Claims (7)

1. A system comprising:

a) ALDH high -DCs (ALDH high -Dendritic Cells), and

b) a radioactive implant configured for use in internal radiation cancer therapy.

2. A system comprising:

a) ALDH high -DCs (ALDH high -Dendritic Cells), and

b) a device configured to emit radiation used during external radiation cancer therapy.

3. A composition comprising: ALDH high -DCs (ALDH high -Dendritic Cells) and radionucleotides.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 17, 2021
From: UNIVERSITY OF MICHIGAN
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 056575/0603 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2015
From: LI, QIAO
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Reel/Frame 035625/0466 →
Continuity (2)
Provisional Application 61717902 · Oct 24, 2012
Related Publication 20150265848A1 · Sep 24, 2015