Method of preventing or reducing the progression of prostate cancer
The embodiments include methods of preventing or reducing the progression of prostate cancer in mammals susceptible to developing prostate cancer, and to methods of reducing the incidence of clinically detected prostate cancer, using compositions containing compounds based on small peptides and a pharmaceutically acceptable carrier. The method includes, but is not limited to, administering the compounds intramuscularly, orally, intravenously, intraprostatically, intrathecally, intratumorally, intranasally, topically, transdermally, etc., either alone or conjugated to a carrier to a mammal in need thereof.
1. A method of reducing the onset of prostate cancer in a mammal susceptible to developing prostate cancer as determined by one or more prostate cancer screening techniques, comprising administering, more than once, to the mammal susceptible to developing prostate cancer a therapeutically effective amount of an isolated peptide comprising the amino acid sequence in SEQ ID NO. 66 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu), wherein the method reduces the onset of prostate cancer by an amount greater than about 15%, when compared to mammals receiving a placebo.
2. The method of claim 1 , wherein the method comprises administration of a therapeutically effective amount of at least one of the peptides as claimed in claim 1 and a carrier.
3. The method of claim 1 , wherein the method comprises administration of a therapeutically effective amount of at least one of the peptides as claimed in claim 1 and at least one and up to 25 additional amino acids flanking either the N-terminus or C-terminus of the isolated peptide of claim 1 .
4. The method of claim 1 , wherein the peptide is administered by a method selected from the group consisting of orally, subcutaneously, intradermally, intranasally, intravenously, intramuscularly, intrathecally, intranasally, intratumorally, topically, and transdermally.
5. The method of claim 1 , wherein the method provides an onset of prostate cancer in a range of from about 0% to about 5%.
6. The method of claim 5 , wherein the method provides an onset of prostate cancer in a range of from about 0% to about 2%.
7. The method of claim 5 , wherein the method provides an onset of prostate cancer in a range of from about 0% to about 1.3%.
8. A method of reducing the progression of prostate cancer in a mammal susceptible to developing prostate cancer as determined by one or more prostate cancer screening techniques, comprising administering, more than once, to the mammal a therapeutically effective amount of an isolated peptide comprising the amino acid sequence in SEQ ID NO. 66 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu), wherein the method reduces the progression of prostate cancer to an amount within the range of from about 0% to less than about 5%.
9. The method of claim 8 , wherein the method comprises administration of a therapeutically effective amount of at least one of the peptides as claimed in claim 8 , and a carrier.
10. The method of claim 8 , wherein the method comprises administration of a therapeutically effective amount of at least one of the peptides as claimed in claim 8 and at least one and up to 25 additional amino acids flanking either the N-terminus or C-terminus of the isolated peptide of claim 8 .
11. The method of claim 8 , wherein the peptide is administered by a method selected from the group consisting of orally, subcutaneously, intradermally, intranasally, intravenously, intraprostatically, intramuscularly, intrathecally, intranasally, intratumorally, topically, and transdermally.
12. The method of claim 8 , wherein the method reduces the progression of prostate cancer to an amount within the range about 0% to about 1%.
13. The method of claim 8 , wherein the method reduces the progression of prostate cancer to an amount of about 0%.
14. The method of claim 8 , wherein the mammal susceptible to developing prostate cancer had a baseline PSA level of ≥2.5.