Method and device for delivering medicine to bone
A method for delivering multiple substances in a delay fashion to a bone of a patient is provided. The method includes providing a cannulated bone screw, creating an aperture in the skin of a patient, and inserting the bone screw into a bone of the patient through the aperture. The method further includes delivering a first substance into the bone through the bone screw, wherein the first substance changes over time into a solid hardened material, and then delivering a second substance into the bone through the bone screw after the first substance changed into a solid hardened material. The solid hardened material of the first substance may be a permeable material that allows the second substance to transport through, or the second substance may transport through the first substance by diffusion, or may reach a desired location in the bone through pores or cracks in the hardened solid material.
1. A method for delivering multiple substances in a delayed fashion to a bone of a patient, comprising:
providing a cannulated bone screw, wherein the bone screw comprises first and second fenestrations disposed along a shaft of the bone screw and connecting to a cannulation of the bone screw;
inserting an insert into the bone screw;
creating an aperture in skin of a patient;
inserting the bone screw into the bone of the patient through the aperture;
delivering a first substance into the bone through the bone screw, wherein the first substance changes over time into an at least partially solid hardened material; and
delivering a second substance into the bone through the bone screw and through the first substance after the first substance has changed into the at least partially solid hardened material;
wherein the first and second substances are delivered into the bone through the insert; and
wherein the insert is moveable within the cannulation of the bone screw to deliver the first substance through at least one of the first and second fenestrations and to deliver the second substance through at least one of the first and second fenestrations.
2. The method of claim 1 , wherein the solid hardened material of the first substance is a permeable material that allows the second substance to transport through.
3. The method of claim 1 , wherein the second substance transports through the first substance by diffusion.
4. The method of claim 1 , wherein the second substance reaches to a desired location in the bone through pores or cracks in the hardened solid materials of the first substance.
5. The method of claim 1 , further comprising delivering a third substance into the bone while the first substance is changing into a solid hardened material.
6. The method of claim 1 , further comprising:
removing the insert without removing the bone screw before delivering the second substance;
treating the insert with a treatment intended to reduce infection in the bone and clean a cannulation of the insert; and
recoupling the treated insert to the bone screw.
7. The method of claim 1 , further comprising providing a second insert and coupling the second insert to the bone screw.
8. The method of claim 1 , wherein the insert is moveable within the cannulation of the bone screw between a first position to deliver the first substance through the first fenestration and a second position to deliver the second substance through the second fenestration.
9. The method of claim 1 , wherein the first substance includes bone cements and the second substance includes at least one of bone morphogenic proteins, osteoprogenitor cells, calcium phosphate, antibiotics, and anti-cancer drugs.
10. A method for delivering multiple substances in a delayed fashion to a bone of a patient, comprising:
providing a cannulated bone screw, wherein the bone screw comprises first and second fenestrations disposed along a shaft of the bone screw and connecting to a cannulation of the bone screw;
inserting an insert into the bone screw;
creating an aperture in skin of a patient;
inserting the bone screw into the bone of the patient through the aperture;
delivering a first substance into the bone through the bone screw, wherein the first substance changes over time into an at least partially solid hardened material;
delivering a second substance into the bone through the bone screw and through the first substance after the first substance has changed into the at least partially solid hardened material;
wherein the first and second substances are delivered into the bone through the insert;
removing the insert without removing the bone screw before delivering the second substance;
treating the insert with a treatment intended to reduce infection in the bone and clean a cannulation of the insert; and
recoupling the treated insert to the bone screw.