Locally injectable dosimetric organ spacer
The present invention relates to a system, a method and a filler for measuring a dose of ionizing radiation received by a pre-determined part of the body during radiotherapy while creating a space between the organ to be irradiated and organs to be protected. The invention also relates to uses of such filler. The system comprises an injectable dosimetric filler, which under the influence of ionizing irradiation undergoes measurable physical and/or chemical changes, while preserving its spatial integrity; a detector system for measuring the physical and/or chemical changes within the radiation sensitive filler by sending an energy wave to the radiation sensitive filler and capturing the signal emitted therefrom; and a control unit for processing the signal captured by the detector system and calculating a dose of ionizing radiation previously or simultaneously received by each part of the volume of the radiation sensitive filler on the basis of said signal.
1. A system for measuring a dose of ionizing irradiation received by a pre-determined body part during a radiotherapy treatment, the system comprising:
a) a viscous or semi-solid radiation sensitive filler adapted for being injected between said predetermined body part and a tissue to be protected from radiation, wherein the radiation sensitive filler is adapted for undergoing a measurable physical and/or chemical change under the influence of ionizing irradiation and for substantially preserving, during said radiotherapy treatment, its initial morphology in order to minimize dose to the tissue to be protected from radiation, the initial morphology being determined by the shape and volume of said radiation sensitive filler upon injection between said predetermined part of the body and said tissue to be protected;
b) a detector system adapted for measuring said physical and/or chemical change within the radiation sensitive filler by sending an energy wave to the radiation sensitive filler and capturing a signal emitted therefrom; and
c) a control unit adapted for processing said captured signal and calculating a dose of ionizing radiation previously or simultaneously received by each part of the volume of the radiation sensitive filler taking said signal into account.
2. The system according to claim 1 , wherein the radiation sensitive filler comprises a suspension of superheated droplets.
3. The system according to claim 2 , wherein the superheated droplets are encapsulated by a polymeric shell.
4. The system according to claim 2 , wherein the superheated droplets are in a stable state and the droplets are adapted for re-condensing when switching the radiation source off such as to spontaneously reset said physical and/or chemical change of said radiation sensitive filler.
5. The system according to claim 2 , wherein the superheated droplets are in a metastable state.
6. The system according to claim 1 , wherein the radiation sensitive filler comprises a suspension of gas-filled microbubbles.
7. The system according to claim 1 , wherein the detector system is a CT scanner.
8. The system according to claim 1 , wherein the detector system is an acoustic readout system.
9. A method for measuring a dose of ionizing irradiation received by a pre-determined body part during a radiotherapy treatment, said method comprising:
a) sending an energy wave to a viscous or semi-solid radiation sensitive filler, the viscous or semi-solid radiation sensitive filler being pre-injected between said predetermined body part and a tissue to be protected from radiation, said radiation sensitive filler being adapted for undergoing a measurable physical and/or chemical change under the influence of ionizing irradiation and for substantially preserving, during said radiotherapy treatment, its initial morphology in order to minimize dose to the tissue to be protected from radiation, the initial morphology being determined by the shape and volume of said radiation sensitive filler after being pre-injected between said predetermined part of the body and said tissue to be protected;
b) capturing a signal emitted by the radiation sensitive medium elicited by said energy wave, whereby said emitted signal has characteristics that reflect said physical and/or chemical change; and
c) processing said captured signal and calculating the dose of ionizing irradiation previously or simultaneously received by each part of the radiation sensitive filler taking said signal into account.
10. A radiation sensitive filler for measuring a dose of ionizing irradiation received by a pre-determined body part during a radiotherapy treatment, said radiation sensitive filler being a viscous or semi-solid radiation sensitive filler adapted for being injected between said predetermined body part and a tissue to be protected from radiation, wherein the radiation sensitive filler is adapted for undergoing a measurable physical and/or chemical change under the influence of ionizing irradiation and for substantially preserving, during said radiotherapy treatment, its initial morphology in order to minimize dose to the tissue to be protected from radiation, the initial morphology being determined by the shape and volume of said radiation sensitive filler upon injection between said predetermined part of the body and said tissue to be protected, said radiation sensitive filler furthermore being adapted for emitting a signal when elicited by an energy wave, whereby said emitted signal has characteristics that reflect said physical and/or chemical change.
11. The radiation sensitive filler according to claim 10 , comprising a viscous medium having liquid droplets dispersed therein and/or comprising a suspension of gas-filled microbubbles.
12. The radiation sensitive filler according to claim 10 , wherein said radiation sensitive filler is biocompatible and biodegradable.
13. The radiation sensitive filler according to claim 10 , wherein said radiation sensitive filler is adapted to preserve its initial morphology in order to minimize dose to the rectum for radiotherapy of the prostate or of the cervix.
14. The radiation sensitive filler according to claim 10 , wherein said radiation sensitive filler is adapted to preserve its initial morphology in order to minimize dose to a bowel and/or at least one kidney for paraspinal, sacral or pelvic radiotherapy.