5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives

1. A compound of formula (I),

wherein:

R represents hydrogen or halo;

R 3 represents hydrogen, hydroxy, halo, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 1-4 alkoxy, C 1-4 hydroxyalkyl, C 1-4 haloalkoxy, —O(CH 2 ) 2 OH or —O(CH 2 ) 2 O C 1-2 alkyl;

R 4 represents hydrogen, halo, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 1-4 alkoxy or C 1-4 haloalkoxy;

R 5 represents hydrogen, halo, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 1-4 alkoxy or C 1-4 haloalkoxy;

m and n represent integers which may be independently selected from 1 and 2; and either

(a) R 1 represents hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 1-4 alkoxy, C 1-2 alkoxy C 1-2 alkyl or C 1-4 haloalkoxy; and

R 2 represents hydrogen, halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 1-4 alkoxy, C 1-4 haloalkoxy, C 1-2 alkoxy C 1-2 alkyl, C 1-4 hydroxyalkyl or cyano; or

(b) R 1 and R 2 are in positions 6 and 5 respectively of the pyridine nucleus and are joined to form a bicyclic system comprising either a 5- or 6-membered carbocyclic ring or a 5- or 6- membered heterocyclic ring which contains heteroatoms selected only from O and S, which is fused to said pyridine nucleus;

or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 wherein n represents 1 and m represents 2.

3. A compound according to claim 2 which is a compound of formula (Ib)

wherein R, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in claim 1 ;

or a pharmaceutically acceptable salt thereof.

4. A compound according to claim 3 which is a compound of formula (Ic)

wherein R, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in claim 1 ;

or a pharmaceutically acceptable salt thereof.

5. A compound according to claim 1 wherein R represents hydrogen or fluoro.

6. A compound according to claim 1 wherein R 3 represents hydrogen, hydroxy, halo, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 1-4 alkoxy or C 1-4 haloalkoxy.

7. A compound according to claim 1 wherein:

R 1 represents hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 1-4 alkoxy or C 1-4 haloalkoxy; and

R 2 represents hydrogen, halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 1-4 alkoxy, C 1-4 haloalkoxy or cyano.

8. A compound according to claim 7 wherein one of R 1 and R 2 is C 1-4 alkyl and the other is hydrogen.

9. A compound according to claim 8 wherein R 1 is hydrogen in the 6-position of the pyridine ring and R 2 is methyl in the 5-position of the pyridine ring.

10. A compound according to claim 1 wherein:

R 1 and R 2 are in positions 6 and 5 respectively of the pyridine ring and are joined to form a bicyclic system comprising either a 5- or 6-membered carbocyclic ring, or a 5- or 6-membered heterocyclic ring, which contains heteroatoms selected from O and S and is fused to said pyridine nucleus, said bicyclic system being selected from the systems listed below:

11. A compound according to claim 1 wherein R 3 , R 4 and R 5 are selected from hydrogen, halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 1-4 alkoxy and cyano.

12. A compound according to claim 1 wherein one of R 3 , R 4 and R 5 is hydrogen and the remainder are substituents other than hydrogen.

13. A compound according to claim 1 wherein two of R 3 , R 4 and R 5 are hydrogen and the remainder is a substituent other than hydrogen.

14. A compound according to claim 12 wherein one of R 3 , R 4 and R 5 is hydrogen and the remainder occupy positions 2- and 6- of the phenyl ring to which they are attached.

15. A compound according to claim 14 wherein one of R 3 , R 4 and R 5 is hydrogen and the remainder are selected from the group consisting of methyl, trifluoromethyl, cyano and halo.

16. A compound according to claim 1 which is selected from the group consisting of:

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-phenyl-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-cyanophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(6-methoxy-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5-cyclopropyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(o-tolyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-chlorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-ethylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(4-ethynylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2,6-difluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2,4-difluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(4-chloro-2-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluoro-4-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluoro-4-methoxyphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2,6-dimethylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-chloro-6-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-chloro-4-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2,4,6-trifluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)-2-fluorobenzoyl)-N-(2-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)-2-fluorobenzoyl)-N-(2,6-difluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)-2-fluorobenzoyl)-N-(2-chloro-6-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-phenyl-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluorophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chlorophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(o-tolyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2,4-difluorophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chloro-6-fluorophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-methylphenyl)-6-(4-(6-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chloro-6-fluorophenyl)-6-(4-(6-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5,6-dimethyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(o-tolyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5,6-dimethyl-2-(7-oxa-2-azaspiro [3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5,6-dimethyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2,4-difluorophenyl)-6-(4-(5,6-dimethyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chloro-6-fluorophenyl)-6-(4-(5,6-dimethyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

and pharmaceutically acceptable salts of any one thereof.

17. A compound according to claim 1 which is selected from the group consisting of:

N-(2-fluoro-6-iodophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-cyclopropyl-6-fluorophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamido)benzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-5,6,7,8-tetrahydroquinoline-3-carboxamido)benzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)quinoline-3-carboxamido)benzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5-cyclopropyl-2-(7-oxa-2-azaspiro[3,5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(4-(2-((2-fluoro-6-methylphenyl)carbamoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-6-carbonyl)phenyl)-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carboxamide;

6-(4-(5-(7-oxa-2-azaspiro[3.5]nonan-2-yl)thieno[3,2-b]pyridine-6-carboxamido)benzoyl)-N-(2,6-difluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-vinylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido) benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-ethynyl-6-fluorophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido) benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2,6-difluorophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2,4,6-trifluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2,6-difluorophenyl)-6-(4-(6-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(6-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2,4,6-trifluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-cyano-6-fluorophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-hydroxyphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-methoxyphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-(2-hydroxyethoxy)phenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-(2-methoxyethoxy)phenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chloro-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido) benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2,6-dichlorophenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-(hydroxymethyl)-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(2-fluoro-4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2,4,6-trifluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5-ethyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chloro-6-fluorophenyl)-6-(4-(5-ethyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-cyano-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-(trifluoromethyl)phenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2,6-dimethylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chloro-6-fluorophenyl)-6-(4-(5-cyclopropyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chloro-6-fluorophenyl)-6-(4-(5-ethynyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chloro-6-fluorophenyl)-6-(4-(5-(methoxymethyl)-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5-fluoro-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5-chloro-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl-2,3,5,6-d4)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-methylphenyl)-6-(4-(5-methoxy-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(5-cyclopropyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-N-(2,6-difluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2,6-difluorophenyl)-6-(4-(5-(prop-1-en-2-yl)-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamido)benzoyl)-N-(2-cyano-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamido)benzoyl)-N-(2,6-difluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamido)benzoyl)-N-(2-chloro-6-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamido)-2-fluorobenzoyl)-N-(2-cyano-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamido)-2-fluorobenzoyl)-N-(2-fluoro-6-methylphenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamido)-2-fluorobenzoyl)-N-(2,6-difluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamido)-2-fluorobenzoyl)-N-(2-chloro-6-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-5,6,7,8-tetrahydroquinoline-3-carboxamido)benzoyl)-N-(2-chloro-6-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(4-(2-((2,6-difluorophenyl)carbamoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-6-carbonyl)phenyl)-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carboxamide;

N-(4-(2-((2-chloro-6-fluorophenyl)carbamoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-6-carbonyl)phenyl)-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)quinoline-3-carboxamido)benzoyl)-N-(2-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)quinoline-3-carboxamido)benzoyl)-N-(2,4-difluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)quinoline-3-carboxamido)benzoyl)-N-(2,6-difluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)quinoline-3-carboxamido)benzoyl)-N-(2-chloro-6-fluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

6-(4-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)quinoline-3-carboxamido)benzoyl)-N-(2,4,6-trifluorophenyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-methyl-phenyl)-6-(4((5-(7-oxa-2-azaspiro[3.5]nonan-2-yl)thieno[3,2-b]pyridine-6-carbonyl)amino)benzoyl)-4,5-dihydrothieno[3,2-d][1]benzazepine-2-carboxamide;

N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(2-oxa-7-azaspiro[3.5]nonan-7-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2,6-difluorophenyl)-6-(4-(5-methyl-2-(2-oxa-7-azaspiro[3.5]nonan-7-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-chloro-6-fluorophenyl)-6-(4-(5-methyl-2-(2-oxa-7-azaspiro[3.5]nonan-7-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-(trifluoromethyl)phenyl)-6-(4-(5-methyl-2-(2-oxa-7-azaspiro[3.5]nonan-7-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(3-oxa-9-azaspiro[5.5]undecan-9-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide;

and pharmaceutically acceptable salts of any one thereof.

18. A method of treatment of RSV infection or lung disease associated with RSV infection in a subject which comprises administering to said subject an effective amount of a compound according to claim 1 .

19. A method of prevention of RSV infection or lung disease associated with RSV infection in a subject which comprises administering to said subject prior to infection an effective amount of a compound according to claim 1 .

20. A method according to claim 18 wherein the RSV infection is infection by viruses of the RSV A strain and/or viruses of the RSV B strain.

21. A pharmaceutical composition comprising a compound according to claim 1 optionally in combination with one or more pharmaceutically acceptable diluents or carriers.

22. A pharmaceutical composition according to claim 21 which comprises a second or further active ingredient.

23. A pharmaceutical composition according to claim 22 wherein the second or further active ingredient is selected from anti-viral agents and anti-inflammatory agents.

24. A method according to claim 19 wherein the RSV infection is infection by viruses of the RSV A strain and/or viruses of the RSV B strain.