Thioamide-modified peptides and uses thereof
View Patent ↗The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
1. A peptide comprising the thioamide-modified amino acid sequence of SEQ ID NO:2, or a salt or solvate thereof,
wherein residue 1 of SEQ ID NO:2 is the N-terminus residue of the peptide.
2. A pharmaceutical composition comprising at least one peptide of claim 1 and a pharmaceutically acceptable carrier.
3. The composition of claim 2 , further comprising at least one additional agent useful for treating or preventing a disease or disorder in a subject.
4. The composition of claim 3 , wherein the disease or disorder comprises at least one selected from the group consisting of diabetes and obesity.
5. The peptide of claim 1 , wherein the C-terminus of the peptide is amidated.
6. The peptide of claim 1 , wherein the C-terminus of the peptide is esterified.
7. The peptide of claim 1 , wherein at least one NH group in the peptide backbone is methylated.
8. The peptide of claim 1 , wherein the N-terminus amino group is methylated or acetylated.