Therapeutic compounds
The invention features therapeutic compounds useful for the treatment of skin diseases (e.g., psoriasis and eczema), infections (microbial, viral, and fungal), and wounds (e.g., cuts and burns). The compounds of the invention include therapeutically-effective amounts of L-Arginine, undecylenic acid, and Rheum Officinale extract. The invention further provides for the administration of the therapeutic compounds to a patient (e.g., a human) suffering from a skin disease, infection, or wound.
1. A therapeutic composition for treating a microbial infection comprising:
L-Arginine or a pharmaceutically acceptable salt thereof in amount between 5% w/v to 50% w/v,
undecylenic acid or a pharmaceutically acceptable salt thereof in an amount between 2% w/v to 50% w/v, and
an extract of Rheum Officinale in an amount between 0.025% w/v to 2.5 w/v.
2. The composition of claim 1 , wherein the amount of L-Arginine is about 50% w/v, the amount of undecylenic acid is about 20% v/v, and the amount of the extract of Rheum Officinale is about 0.25% w/v.
3. The composition of claim 1 further comprising a cooling or heating additive.
4. The composition of claim 3 , wherein said cooling additive is menthol.
5. The composition of claim 1 in combination with a pharmaceutically acceptable excipient, diluent, or carrier.
6. The composition of claim 5 , wherein said excipient, diluent, or carrier is optimized for topical application.
7. A method for treating a microbial infection in a subject in need thereof, the method comprising administering to a said subject a therapeutically effective amount of a composition comprising:
L-Arginine in amount between 5% w/v to 50% w/v,
undecylenic acid in an amount between 2% w/v to 50% w/v, and
an extract of Rheum Officinale in an amount between 0.025% w/v to 2.5 w/v.
8. The method of claim 7 , wherein the amount of L-Arginine is about 50% w/v, the amount of undecylenic acid is about 20% v/v, and the amount of the extract of Rheum Officinale is about 0.25% w/v.
9. A kit comprising (i) the therapeutic composition of claim 2 ; and (ii) instructions for utilizing said composition.