IP Library › Granted Patent US 10,202,367
Granted Patent B2
US 10,202,367 · App. 15/317,864 · Granted Feb 12, 2019

Heterocyclic compounds and methods of use thereof

Inventors: Tsanyang Liang (Potomac, MD); Zongyi Hu (Potomac, MD); Juan Jose Marugan (Gaithersburg, MD); Noel Terrence Southall (Potomac, MD); Shanshan He (North Bethesda, MD); Xin Hu (Frederick, MD); Jingbo Xiao (Rockville, MD); Marc Ferrer (Potomac, MD); Wei Zheng (Potomac, MD); Kevin J. Frankowski (Lawrence, KS); Frank J. Schoenen (Lawrence, KS); Kelin Li (Lawrence, KS)
Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Kansas
C07D413/06A61K31/4178A61K31/454A61K31/4545A61K31/496A61K31/5377A61K31/7056A61K31/7068A61K38/07A61K38/13A61K38/212C07D413/14C07D417/14C07D471/08Y02A50/385
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Quick Facts
Patent No.
US 10,202,367
App. No.
15/317,864
Granted
Feb 12, 2019
Kind
B2
Abstract

Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R 1 , A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.

Claims (11)

1. A compound selected from:

or a pharmaceutically acceptable salt thereof, stereoisomer thereof, or mixture comprising stereoisomers thereof.

2. A pharmaceutical composition comprising a compound, salt, stereoisomer, or a mixture of stereoisomers of claim 1 and a pharmaceutically acceptable carrier.

3. A kit comprising:

(a) a compound of claim 1 , and

(b) at least one anti-hepatitis C compound other than the compound of claim 1 .

4. A compound selected from:

5. A pharmaceutical composition comprising a compound, salt, stereoisomer, or a mixture of stereoisomers of 4 and a pharmaceutically acceptable carrier.

6. A kit comprising:

(a) a compound of claim 4 , and

(b) at least one anti-hepatitis C compound other than the compound of claim 4 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2017
From: LIANG, TSANYANG JAKE; HU, ZONGYI; MARUGAN, JUAN JOSE; SOUTHALL, NOEL TERRENCE; HU, XIN; XIAO, JINGBO; HE, SHANSHAN; FERRER, MARC; ZHENG, WEI; FRANKOWSKI, KEVIN J.; SCHOENEN, FRANK J.; LI, KELIN
To: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF KANSAS
Reel/Frame 043638/0165 →
Continuity (2)
Provisional Application 62011462 · Jun 12, 2014
Related Publication 20170114053A1 · Apr 27, 2017