Ameliorating nervous systems disorders
The present disclosure provides methods for the treatment of a mammal having a neurological condition, disease, or injury. The methods involve increasing the number of functional GABAergic interneurons at or near the site of the neurological disease, injury, or condition.
1. A method for improving motor activity in the central nervous system (CNS) of a mammal having impaired motor activity, comprising:
transplanting medial ganglionic eminence (MGE) precursor cells into the CNS of the mammal.
2. The method of claim 1 , wherein the MGE precursor cells are transplanted into the brain of the mammal.
3. The method of claim 2 , wherein the MGE precursor cells are transplanted in or near the striatum.
4. The method of claim 1 , wherein the MGE precursor cells are transplanted into the spinal cord of the mammal.
5. The method of claim 1 , wherein the MGE precursor cells are transplanted by injection.
6. A method for improving motor function in a mammal affected with a nervous system disorder and in need of improved motor function, comprising:
transplanting medial ganglionic eminence (MGE) precursor cells into the nervous system of the mammal; and
allowing the MGE precursor cells to migrate and integrate into the nervous system of the mammal and change the balance of excitatory and inhibitory signals in the nervous system; and
assessing the mammal for an improvement in motor function.
7. The method of claim 6 , wherein the nervous system disorder is a central nervous system (CNS) disorder.
8. The method of claim 7 , wherein the CNS disorder is Parkinson's disease.
9. The method of claim 7 , wherein the MGE precursor cells are injected into the brain.
10. The method of claim 6 , wherein the nervous system disorder is a movement disorder.
11. The method of claim 6 , wherein the nervous system disorder is a nerve injury.
12. The method of claim 11 , wherein the nervous system disorder is spinal cord injury.
13. The method of claim 12 , wherein the MGE precursor cells are injected into the spinal cord.
14. A method for improving motor activity in a mammal having motor impairment and in need of improved motor activity, comprising:
transplanting medial ganglionic eminence (MGE) precursor cells into the nervous system of the mammal; and
allowing the MGE precursor cells to change the balance of excitatory and inhibitory signals in the nervous system of the mammal; and
assessing the mammal for an improvement in motor activity.
15. The method of claim 14 , wherein the MGE precursor cells are transplanted into the brain of the mammal.
16. The method of claim 15 , wherein the MGE precursor cells are transplanted in or near the striatum.
17. The method of claim 14 , wherein the MGE precursor cells are transplanted into the spinal cord of the mammal.
18. The method of claim 14 , wherein the MGE precursor cells are transplanted by injection.