IP Library Granted Patent US 10,209,232
Granted Patent B2
US 10,209,232 · App. 15/104,668 · Granted Feb 19, 2019

Specific, reversible, and wide-dynamic range sensor for real time detection of carbon dioxide

Inventors: Erica Forzani (Mesa, AZ); Nongjian Tao (Fountain Hills, AZ); Di Zhao (Tempe, AZ); Francis Tsow (Tempe, AZ)
Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
G01N33/004A61B5/0022A61B5/0059A61B5/082G01N21/8483G01N33/497A61B2560/0242A61B2560/0252
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Quick Facts
Patent No.
US 10,209,232
App. No.
15/104,668
Granted
Feb 19, 2019
Kind
B2
Abstract

A CO 2 detection chamber includes a gas inlet and a gas outlet. A CO 2 sensor is housed in the CO 2 detection chamber, where the sensor includes a reversible and selective pH-sensitive nanocomposite sensor element for CO 2 detection, and a hydrophobic surface. A flowmeter, a thermistor and a humidity sensor operate to read flow and compensate for humidity conditions. A light source is coupled to receive signals from the CO 2 sensor and respond to color changes in the sensor by transducing the color change into a light intensity change. A photodiode receives signals from the light source and responds to light intensity changes by transducing the light intensity changes into electronic signals representing varying degrees of light intensity. Data representing CO 2 measurements is transmitted for display to a mobile device.

Claims (26)

1. A pocket-sized multifunctional CO 2 detector for use in predicting pulmonary disease comprising:

a non-invasive CO2 detection chamber including a gas inlet and a gas outlet;

a CO 2 sensor housed in the CO 2 detection chamber in direct fluid communication with the gas inlet, where the sensor includes a reversible and selective pH-sensitive nanocomposite sensor element including m-cresol purple, thymol blue, or bromothymol blue for CO 2 detection, and a porous hydrophobic surface with microstructures, wherein the porous hydrophobic surface includes a plurality of microstructures made of fluorinated polymers or fluorinated surfaces that have large surface-to-volume ratio providing dense reactive sites to promote the formation of nano-sized reaction clusters;

a flowmeter;

a thermistor;

a humidity sensor;

at least one light source coupled to receive signals from the CO 2 sensor and respond to color changes in the sensor by transducing the color change into a light intensity change;

at least one photodiode coupled to receive signals from the at least one light source and which responds to light intensity changes by transducing the light intensity changes into electronic signals representing varying degrees of light intensity;

a power source coupled to power the CO 2 detector elements; and

a microcontroller electronically coupled to the flowmeter, thermistor, the humidity sensor and the photodiode.

2. The detector of claim 1 further comprising:

a transmitter; and

a mobile device coupled to receive data transmitted by the transmitter.

3. The detector of claim 2 wherein the transmitter includes an antenna for wireless transmission of data.

4. The detector of claim 2 wherein the mobile device comprises a user interface including a display screen.

5. The detector of claim 2 wherein the mobile device comprises:

a computer application residing in the mobile device or accessible thereby to control the user interface and provide the real-time data display, storage, and transmission of data transmitted from the detector.

6. The detector of claim 5 wherein the computer application comprises:

a user profile module;

a test module; and

a history module, where the modules operate and respond to inputs from the user interface.

7. The detector of claim 6 where the test module comprises a breath CO 2 detection and environmental CO 2 detection mode wherein CO 2 concentration as a function of time is plotted.

8. The detector of claim 6 where the test module comprises environmental CO 2 detection.

9. The detector of claim 1 wherein the porous hydrophobic surface is coated with sensing chemicals affixed to a sensor cartridge.

10. The detector of claim 9 wherein the nano-sized reaction clusters include hydrophilic pH-sensitive molecular probes.

11. The detector of claim 10 wherein the hydrophilic pH-sensitive molecular probes comprise a pH indicator, an amine buffer and phase transfer agents.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 3, 2018
From: ARIZONA STATE UNIVERSITY, TEMPE CAMPUS
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 046473/0516 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 5, 2016
From: FORZANI, ERICA; TAO, NONGJIAN; ZHAO, DI; TSOW, FRANCIS
To: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Reel/Frame 039949/0652 →
Continuity (2)
Provisional Application 61923048 · Jan 2, 2014
Related Publication 20160313290A1 · Oct 27, 2016