Beta-lactamase inhibitors
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
1. A compound represented by the following structures, or a stereoisomer thereof:
2. The compound of claim 1 , wherein the compound is represented by the following structure:
3. A pharmaceutical composition comprising a compound of claim 1 or 2 ; and a pharmaceutically acceptable excipient.
4. The pharmaceutical composition of claim 3 , further comprising a beta-lactam antibiotic.
5. The pharmaceutical composition of claim 4 , wherein the beta-lactam antibiotic is a penicillin, cephalosporin, carbapenem, monobactam, bridged monobactam, or a combination thereof.
6. A pharmaceutically acceptable salt of a compound represented by the following structures, or a stereoisomer thereof:
or a solvate thereof.
7. The pharmaceutically acceptable salt of claim 6 , wherein the compound is represented by the following structure:
or a solvate thereof.
8. A pharmaceutical composition comprising a pharmaceutically acceptable salt of claim 6 or 7 ; and a pharmaceutically acceptable excipient.
9. The pharmaceutical composition of claim 8 , further comprising a beta-lactam antibiotic.
10. The pharmaceutical composition of claim 9 , wherein the beta-lactam antibiotic is a penicillin, cephalosporin, carbapenem, monobactam, bridged monobactam, or a combination thereof.