IP Library › Granted Patent US 10,220,071
Granted Patent B2
US 10,220,071 · App. 15/992,874 · Granted Mar 5, 2019

Microcin and uses thereof

Inventors: Douglas R. Call (Pullman, WA); Lisa Orfe (Pullman, WA)
Assignee: Washington State University
A61K38/164A01N37/46A01N63/00A01N63/02A61K35/74
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Quick Facts
Patent No.
US 10,220,071
App. No.
15/992,874
Granted
Mar 5, 2019
Kind
B2
Abstract

Microcin MccPDI and bacteria harboring the mcpM gene which encodes MccPDI limit growth of and/or kill pathogenic bacteria such as pathogenic Escherichia coli ( E. coli ) and/or Shigella bacteria via proximity-dependent inhibition (PDI).

Claims (5)

1. A composition comprising

microcin MccPDI having one or more of a sequence of SEQ ID NO: 77 or a functional variant thereof and/or SEQ ID NO:24 or a functional variant thereof, wherein said functional variant has a sequence at least 95% identical to SEQ ID NO: 77 or SEQ ID NO:24; and an oxidizing agent.

2. The composition of claim 1 , wherein said composition further comprises at least 10% oxidizing agent.

3. The composition of claim 1 , wherein said composition further comprises at least 20% oxidizing agent.

4. The composition of claim 1 , wherein said composition further comprises dimethyl sulfoxide (DMSO).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 30, 2018
From: CALL, DOUGLAS R.; ORFE, LISA
To: WASHINGTON STATE UNIVERSITY
Reel/Frame 045937/0270 →
Continuity (4)
Division 15268666 · Sep 19, 2016
Continuation In Part 14407975
Provisional Application 61660616 · Jun 15, 2012
Related Publication 20180264078A1 · Sep 20, 2018