Suture line administration technique using botulinum toxins

1. A method for treating a patient suffering from a headache, comprising the step of administering a Clostridial toxin between the periosteum and the aponeurotic fascia of the scalp in the vicinity of at least one suture line of the patient's skull, wherein the administration alleviates at least one symptom of the headache, thereby treating the patient suffering from the headache.

2. The method according to claim 1 , wherein the Clostridial neurotoxin is a botulinum toxin.

3. The method according to claim 1 , wherein the headache is selected from the group consisting of a sinus headache, a tension headache, a migraine headache, a cluster headache and a cervogenic headache.

4. The method according to claim 1 , wherein the at least one suture line is selected from the group consisting of frontal suture, squamous suture, occipitomastoid suture, coronal suture, lambdoid suture and sagittal suture.

5. The method according to claim 2 , wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C 1 , D, E, F and G.

6. The method according to claim 5 , wherein the botulinum toxin is botulinum toxin type A.

7. The method according to claim 6 , wherein amount of botulinum toxin type A administered is from about 5 units to about 1000 units.

8. The method according to claim 1 , wherein the headache is an episodic migraine or a chronic migraine.

9. The method of claim 1 , further comprising the step of administering the Clostridial toxin in the vicinity of a second suture line.

10. The method of claim 1 , wherein the Clostridial neurotoxin is administered at about 1.5 cm, about 1.0 cm, or about 0.5 cm from the at least one suture line.

11. A method for alleviating a headache pain, comprising the step of determining the location of at least one suture line; and administering a therapeutically effective amount of botulinum toxin type A to a patient in need thereof, wherein the botulinum toxin type A is administered between the periosteum and the aponeurotic fascia of the scalp in the vicinity of the at least one suture line of the patient's skull, thereby alleviating the headache pain.

12. The method of claim 11 , wherein the at least one suture line is selected from the group consisting of frontal suture, squamous suture, coronal suture, lambdoid suture, occipitomastoid suture and sagittal suture.

13. The method of claim 11 , wherein the amount of administered botulinum toxin type A is from about 5 units to about 1000 units.

14. The method according to claim 12 , wherein two or more of the frontal, squamous, coronal, lamboidal and sagittal sutures are administered botulinum toxin type A.

15. The method of claim 11 , wherein the administration step includes the step of inserting a needle of a syringe containing the botulinum toxin type A at a needle penetration point, and positioning the needle along the at least one suture line so that the botulinum toxin type A is administered linearly along at least a portion of the at least one suture line.

16. The method of claim 11 , further comprising the step of administering the botulinum toxin type A in the vicinity of a second suture line.

17. The method of claim 15 , wherein one needle penetration point is utilized to administer the botulinum toxin type A in the vicinity of at least two suture lines.

18. The method of claim 11 , wherein the botulinum toxin type A is administered at about 1.5 cm, about 1.0 cm, or about 0.5 cm from the at least one suture line.

19. The method of claim 1 , wherein the administering is subdermal or subcutaneous.

20. The method of claim 11 , wherein the administrating is subdermal or subcutaneous.