IP Library Granted Patent US 10,226,441
Granted Patent B2
US 10,226,441 · App. 15/534,319 · Granted Mar 12, 2019

Aging inhibitor

Inventors: Naoki Higashi (Ota-ku, JP); Masahiro Nakanishi (Takayama, JP)
Assignee: NIHON SIZEN HAKKOH CO., LTD.
A61K31/198A23K10/12A23K50/50A23L2/52A23L33/105A61K8/99A61K31/19A61K31/192A61K31/194A61K31/196A61K31/197A61K31/352A61K31/353A61K31/401A61K31/405A61K31/4172A61K35/744A61K36/03A61K36/062A61K36/064A61K36/07A61K36/16A61K36/185A61K36/23A61K36/28A61K36/282A61K36/31A61K36/39A61K36/42A61K36/44A61K36/48A61K36/49A61K36/52A61K36/535A61K36/60A61K36/605A61K36/73A61K36/736A61K36/75A61K36/752A61K36/78A61K36/81A61K36/87A61K36/88A61K36/888A61K36/899A61K36/8945A61K36/8962A61K36/8967A61K36/8994A61K36/8998A61K36/9066A61K36/9068A23V2002/00
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Quick Facts
Patent No.
US 10,226,441
App. No.
15/534,319
Granted
Mar 12, 2019
Kind
B2
Abstract

An object of the present invention is to provide a senescence retarding agent that delays the onset of senescence symptoms and extends longevity, and is superior in safety. The senescence retarding agent of the present invention that achieves the object is characterized by containing a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following: (a) a koji mold-fermented product of one or more kinds of beans and/or cereals selected from the group consisting of barley, black soybean, red rice, black rice, adzuki bean, adlay, Japanese millet, foxtail millet, and millet; (b) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of fruits selected from the group consisting of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (Japanese persimmon), papaya , nashi (Japanese pear), watermelon, ume (Japanese apricot), fig, karin (Chinese quince), pumpkin, kumquat, yuzu (Chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (Japanese plum); (c) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of root crops and/or potatoes selected from the group consisting of murasaki-imo (purple sweet potato), kikuimo (Jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (Japanese yam), daikon (Japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and turmeric; (d) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of flowers and/or leaf vegetables selected from the group consisting of cabbage, shiso ( perilla ), mulberry leaves, dokudami (Korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion; (e) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seaweeds selected from the group consisting of kombu (sea tangle), wakame ( Undaria pinnatifida ), and mozuku ( Nemacystus decipiens ); (f) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seeds selected from the group consisting of black sesame seeds, walnuts, and ginkgo nuts; and (g) a yeast- and/or lactic acid bacterium-fermented product of one or two kinds of mushrooms selected from the group consisting of maitake ( Grifola frondosa ) and shiitake ( Lentinus edodes ).

Claims (128)

1. A senescence retarding agent, comprising a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following:

(a) a koji mold-fermented product of barley, black soybean, red rice, black rice, adzuki bean, adlay, Japanese millet, foxtail millet, and millet;

(b) a yeast-and/or lactic acid bacterium-fermented product of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (Japanese persimmon), papaya , nashi (Japanese pear), watermelon, ume (Japanese apricot), fig, karin (Chinese quince), pumpkin, kumquat, yuzu (Chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (Japanese plum);

(c) a yeast-and/or lactic acid bacterium-fermented product of murasaki-imo (purple sweet potato), kikuimo (Jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (Japanese yam), daikon (Japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and turmeric;

(d) a yeast-and/or lactic acid bacterium-fermented product of cabbage, shiso (perilla), mulberry leaves, dokudami (Korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion;

(e) a yeast-and/or lactic acid bacterium-fermented product of kombu (sea tangle), wakame ( Undaria pinnatifida ), and mozuku ( Nemacystus decipiens );

(f) a yeast-and/or lactic acid bacterium-fermented product of black sesame seeds, walnuts, and ginkgo nuts; and

(g) a yeast-and/or lactic acid bacterium-fermented product of maitake ( Grifola frondosa ) and shiitake ( Lentinus edodes ).

2. The senescence retarding agent according to claim 1 , wherein the plant fermentation product comprises the following amino acids in amounts per 100 g of the plant fermentation product:

Arginine

0.2 to 0.6

g

Lysine

0.1 to 0.7

g

Histidine

0.1 to 0.4

g

Phenylalanine

0.2 to 0.8

g

Tyrosine

0.1 to 0.6

g

Leucine

0.3 to 1.2

g

Isoleucine

0.2 to 0.8

g

Methionine

0.05 to 0.30

g

Valine

0.2 to 0.9

g

Alanine

0.2 to 0.9

g

Glycine

0.2 to 0.7

g

Proline

0.4 to 1.2

g

Glutamic acid

1.2 to 3.0

g

Serine

0.2 to 0.8

g

Threonine

0.2 to 0.7

g

Aspartic acid

0.4 to 1.5

g

Tryptophan

0.03 to 0.15

g

Cystine

0.05 to 0.40

g.

3. The senescence retarding agent according to claim 1 , wherein the plant fermentation product comprises the following organic acids in amounts per 100 g of the plant fermentation product:

Citric acid

0.5 to 1.2

g

Malic acid

0.05 to 0.5

g

Succinic acid

0.04 to 0.3

g

Lactic acid

0.5 to 6.0

g

Formic acid

0.01 to 0.1

g

Pyruvic acid

0.005 to 0.05

g

Free γ-aminobutyric acid

0.01 to 0.05

g.

4. The senescence retarding agent according to claim 1 , wherein the plant fermentation product comprises the following polyphenols in amounts per 1 g of the plant fermentation product:

Caffeic acid

20 to 50

μg

o-aminobenzoic acid

10 to 25

μg

Ferulic acid

40 to 70

μg

p-Coumaric acid

15 to 40

μg

Daizein

40 to 65

μg

Genistein

65 to 90

μg

Glycitein

2 to 8

μg

Quercetin

3 to 12

μg

Hesperetin

200 to 300

μg

Naringenin

30 to 60

μg.

5. The senescence retarding agent according to claim 1 , comprising at least one lactic acid bacterium selected from the group consisting of Pediococcus acidilacti ( P. acidilacti ), Lactobacillus brevis ( L. brevis ), Leuconostoc mesenteroides ( L. mesenteroides ), Lactobacillus plantarum ( L. plantarum ), Lactococcus lactis ( L. lactis ), Lactobacillus sakei ( L. sakei ), Pediococcus pentosaceus ( P. pentosaceus ), Lactobacillus casei ( L. casei ), and Lactobacillus curvatus ( L. curvatus ).

6. The senescence retarding agent according to claim 1 , comprising at least one yeast selected from the group consisting of Saccharomyces cerevisiae ( S. cerevisiae ) and Zygosaccharomyces rouxii ( Z. rouxii ).

7. A food or drink comprising the senescence retarding agent according to claim 1 .

8. The senescence retarding agent according to claim 1 , which is a medicament.

9. A longevity extending agent, comprising a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following:

(a) a koji mold-fermented product of barley, black soybean, red rice, black rice, adzuki bean, adlay, Japanese millet, foxtail millet, and millet;

(b) a yeast-and/or lactic acid bacterium-fermented product of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (Japanese persimmon), papaya , nashi (Japanese pear), watermelon, ume (Japanese apricot), fig, karin (Chinese quince), pumpkin, kumquat, yuzu (Chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (Japanese plum);

(c) a yeast-and/or lactic acid bacterium-fermented product of murasaki-imo (purple sweet potato), kikuimo (Jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (Japanese yarn), daikon (Japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and numeric;

(d) a yeast-and/or lactic acid bacterium-fermented product of cabbage, shiso (perilla), mulberry leaves, dokudami (Korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion;

(e) a yeast-and/or lactic acid bacterium-fermented product of kombu (sea tangle), wakame ( Undaria pinnatifida ), and mozuku ( Nemacystus decipiens );

(f) a yeast-and/or lactic acid bacterium-fermented product of black sesame seeds, walnuts, and ginkgo nuts; and

(g) a yeast-and/or lactic acid bacterium-fermented product of maitake ( Grifola frondosa ) and shiitake ( Lentinus edodes ).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 8, 2017
From: HIGASHI, NAOKI; NAKANISHI, MASAHIRO
To: NIHON SIZEN HAKKOH CO., LTD.
Reel/Frame 042652/0835 →
Priority Claims (1)
JP 2014-248884 · Dec 9, 2014 · national
Continuity (1)
Related Publication 20170360733A1 · Dec 21, 2017
Cited By (4)
US 12,239,622 US 12,472,159 US 12,527,759 US 12,622,886