Thiopicolinamide compounds with fungicidal activity
This disclosure relates to thiopicolinamides of Formula I and their use as fungicides.
1. A composition for the control of a fungal pathogen including mixtures of at least one of the compounds of Formula I,
wherein:
R 1 is hydrogen or C 1 -C 5 alkyl, substituted with 0,1 or multiple R 6 ;
R 2 is hydrogen, C 1 -C 5 alkyl or cycloalkyl, each optionally substituted with 0,1 or multiple R 6 ;
R 3 is alkyl, cycloalkyl, alkenyl, aryl or heteroaryl, each optionally substituted with 0,1 or multiple R 6 ;
R 4 is alkyl, cycloalkyl, alkenyl, aryl, heteroaryl, alkoxy, aryloxy, heteroaryloxy, each optionally substituted with 0,1 or multiple R 6 ;
R 5 is hydrogen,—C(O)R 7 , or—CH 2 OC(O)R 7 ;
R 6 is hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkynyl, alkoxy, cyano or heterocyclyl, each optionally substituted with 0,1 or multiple R 8 ;
R 7 is from alkyl, alkoxy, or aryl, each substituted with 0,1 or multiple R 6 ;
R 8 is hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkoxy, or heterocyclyl;
and
a phytologically acceptable carrier material.
2. The composition according to claim 1 , wherein R 5 is hydrogen.
3. The composition according to claim 2 , wherein R 1 is methyl, R 2 is C 1 -C 5 alkyl, R 3 and R 4 independently are aryl, each optionally substituted with 0, 1, or multiple R 6 .
4. The composition according to claim 1 , wherein R 5 is chosen from —C(O)R 7 , or —CH 2 OC(O)R 7 .
5. The composition according to claim 4 , wherein R 7 is alkyl, optionally substituted with 0, 1, of multiple R 6 .
6. The composition according to claim 5 , wherein R 1 is methyl, R 2 is C 1 -C 5 alkyl, R 3 and R 4 independently are aryl, each optionally substituted with 0, 1, or multiple R 6 .
7. The compound according to claim 6 , wherein R 7 is chosen from —CH 3 , —CH 2 OCH 2 CH 3 , —CH 2 CH 2 OCH 3 , —CH(CH 3 ) 2 , —CH 2 CH 2 CH 2 CH 3 , or -cyclopropyl.