Compositions comprising

1. A composition comprising at least two Neisseria meningitidis antigens selected from a group consisting of a trypsin-like serine protease auto-transporter antigen, an NalP antigen, and a TbpB antigen,

wherein said trypsin-like serine protease auto-transporter antigen is in the form of a polypeptide selected from the polypeptides consisting of

(I) a mutant of a full-length mature N. meningitidis trypsin-like serine protease auto-transporter that lacks or has reduced trypsin-like serine protease activity and/or does not contain any cleavage site able/susceptible to be cleaved by a trypsin-like serine protease;

(II) (a) a fragment of a full-length mature trypsin-like serine protease auto-transporter of N. meningitidis , said fragment consisting of

(i) a protease domain of a trypsin-like serine protease auto-transporter of N. meningitidis;

(ii) a protease domain and all or part of an α-peptide domain of a trypsin-like serine protease auto-transporter of N. meningitidis ; or

(iii) a protease domain, an α-peptide domain and a part of a β-domain comprising at least one and no more than eleven β-sheets of a trypsin-like serine protease auto-transporter of N. meningitidis; or

(b) a mutant of said fragment (II)(a) that lacks or has reduced trypsin-like serine protease activity and/or does not contain any cleavage site able/susceptible to be cleaved by a trypsin-like serine protease; and

(III) a fusion polypeptide comprising

a first fragment fused to a second fragment,

wherein said first fragment consists of

a protease domain or a protease sub-domain of a first full-length mature trypsin-like serine protease auto-transporter of N. meningitidis , or

a mutant of a protease domain or a protease sub-domain of a first trypsin-like serine protease auto-transporter of N. meningitidis which lacks or has reduced trypsin-like serine protease activity and/or does not contain any cleavage site able/susceptible to be cleaved by a trypsin-like serine protease,

and said second fragment consists of an α-peptide domain, and optionally a part of a β-domain, of a second full-length mature trypsin-like serine protease auto-transporter of N. meningitidis;

wherein the first and second trypsin-like serine protease auto-transporters are different;

wherein the C-terminus of the first fragment is fused to the N-terminus of the second fragment; and

wherein said polypeptide does not comprise the said full-length mature trypsin-like serine protease auto-transporter of N. meningitidis,

wherein said NalP antigen is in the form of a polypeptide comprising

(I) a fragment of a full-length mature N. meningitidis NalP protein which full-length mature N. meningitidis NalP protein comprises (a) a passenger domain comprising a subtilisin-like serine protease triad and (b) a beta-domain comprising a translocator domain, an alpha-peptide and a beta-core composed of twelve beta-sheets; said NalP fragment comprising

(i) at the N-terminus, the NalP passenger domain;

(ii) at the C-terminus, the beta-domain comprising the translocator domain, the alpha-peptide and at least one and no more than eleven beta-sheets;

wherein said polypeptide does not comprise a full-length mature N. meningitidis NalP protein; or

(II) a mutant of said NalP fragment (I) which lacks or has reduced subtilisin-like serine protease activity and/or does not contain any cleavage site able to be cleaved by a subtilisin-like serine protease;

and wherein said TbpB antigen is devoid of a signal peptide sequence and of the cysteine residue following this signal peptide sequence in the full-length TbpB of N. meningitidis.

2. A composition according to claim 1 , which comprises (i) the trypsin-like serine protease auto-transporter antigen and (ii) the NalP antigen and/or TbpB antigen.

3. A composition according to claim 1 , wherein the TbpB antigen is of isotype II.

4. A composition according to claim 3 , which further comprises the TbpB antigen of isotype I.

5. A composition according to claim 1 , which further comprises an additional N. meningitidis protein antigen.

6. A composition according to claim 2 , which is a bivalent composition comprising the trypsin-like serine protease auto-transporter antigen and the NalP antigen.

7. A composition according to claim 2 , which is a bivalent composition comprising the trypsin-like serine protease auto-transporter antigen and the TbpB antigen.

8. A composition according to claim 2 , which is a trivalent composition comprising (i) the trypsin-like serine protease auto-transporter antigen, (ii) the NalP antigen and (iii) the TbpB antigen.

9. A composition according to claim 4 , which is a trivalent composition comprising (i) the trypsin-like serine protease auto-transporter antigen, (ii) the TbpB antigen of isotype II and (iii) the TbpB antigen of isotype I.

10. A composition according to claim 4 , which is a quadrivalent composition comprising (i) the IgA1P antigen, (ii) the NalP antigen, (iii) the TbpB antigen of isotype II and (iv) the TbpB antigen of isotype I.

11. A composition according to claim 3 , wherein the TbpB antigen of isotype II is the TbpB of strain M982.

12. A composition according to claim 4 , wherein the TbpB antigen of isotype I is the TbpB of strain B16B6.

13. A composition according to claim 4 , wherein the TbpB antigen of isotype I is lipidated.

14. A composition according to claim 1 , wherein the NalP antigen is of strain MC58.

15. A composition according to claim 14 , wherein the NalP antigen comprises the amino acid sequence SEQ ID NO: 7.

16. A composition according to claim 1 , wherein the trypsin-like serine protease auto-transporter antigen is the IgA1P antigen.

17. A composition according to claim 16 , wherein the IgA1P antigen is of strain MC58.

18. A composition according to claim 17 , wherein the IgA1P antigen comprises an amino acid sequence selected from SEQ ID NO: 8 and SEQ ID NO: 9.

19. A composition according to claim 1 , wherein the trypsin-like serine protease auto-transporter antigen is a fusion polypeptide comprising or consisting of:

a first fragment fused to a second fragment:

(1) said first fragment consisting of:

a protease domain or a protease sub-domain of a first full-length mature trypsin-like serine protease auto-transporter of N. meningitidis , or

a mutant of a protease domain or a protease sub-domain of a first trypsin-like serine protease auto-transporter of N. meningitidis which lacks or has reduced trypsin-like serine protease activity and/or does not contain any cleavage site able/susceptible to be cleaved by a trypsin-like serine protease,

(2) said second fragment consisting of:

an α-peptide domain, and optionally a part of a β-domain, of a second full-length mature trypsin-like serine protease auto-transporter of N. meningitidis;

wherein the first and second trypsin-like serine protease auto-transporters are different;

wherein the C-terminus of the first fragment is fused to the N-terminus of the second fragment; and

wherein said polypeptide does not comprise the said full-length mature trypsin-like serine protease auto-transporter of N. meningitidis.

20. A composition according to claim 19 , wherein the trypsin-like serine protease auto-transporter antigen comprises an amino acid sequence consisting in SEQ ID NO: 10.

21. A composition according to claim 1 , which further comprises a N. meningitidis LOS.

22. A composition according to claim 21 , wherein the LOS is detoxified in liposomes.

23. A composition according to claim 9 , wherein the TbpB antigen of isotype II is the TbpB of strain M982.

24. A composition according to claim 10 , wherein the TbpB antigen of isotype II is the TbpB of strain M982.

25. A composition according to claim 9 , wherein the TbpB antigen of isotype I is the TbpB of strain B16B6.

26. A composition according to claim 10 , wherein the TbpB antigen of isotype I is the TbpB of strain B16B6.

27. A composition according to claim 9 , wherein the TbpB antigen of isotype I is lipidated.

28. A composition according to claim 10 wherein the TbpB antigen of isotype I is lipidated.

29. A composition according to claim 12 , wherein the TbpB antigen of isotype I is lipidated.

30. A composition according to claim 8 , wherein the NalP antigen is of strain MC58.

31. A composition according to claim 10 , wherein the NalP antigen is of strain MC58.