Enhanced affinity ligands
The present invention relates to ligands, nanocrystal complexed with the ligands and their use for bio-imaging.
1. A ligand having colloidal stability properties and having the following formula II:
wherein
R A has the formula -L A -M A :
wherein m is an integer ranging from 1 to 5, and p is an integer ranging from 1 to 6;
R B has the formula -L B -M B :
wherein:
q is an integer ranging from 1 to 5,
s is an integer ranging from 1 to 5, and
R 12 , R 13 , R 14 and R 15 are each independently H, or a group selected from an alkyl, alkenyl, aryl, hydroxyl, halogen, alkoxy and carboxylate; and
each of x and y is independently a positive integer,
R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 can be independently H, or a group selected from an alkyl, alkenyl, aryl, hydroxyl, halogen, alkoxy, or carboxylate,
wherein the ligand has a molecular weight from about 1 000 g/mol to about 50 000 g/mol.
2. The ligand according to claim 1 , wherein x+y is ranging from 5 to 500.
3. The ligand according to claim 1 , being functionalized with at least one molecular probe and/or targeting group.
4. A nanocrystal which is complexed with at least one ligand according to claim 1 .
5. The nanocrystal according to claim 4 , wherein said nanocrystal is a 0D, 1D, or 2D nanocrystal.
6. The nanocrystal according to claim 4 , wherein said nanocrystal is a nanosheet, a nanorod, a nanoplatelet, a nanoplate, a nanoprism, a nanowall, a nanodisk, a nanoparticle, a nanowire, a nanopowder, a nanotube, a nanotetrapod, a nanoribbon, a nanobelt, a nanoneedle, a nanocube, a nanoball, a nanocoil, a nanocone , a nanopiller, a nanoflower , or a quantum dot.