Micro- and nano-quantity sleep enhancing nutrient composition and method of enhancing central nervous system protein clearance using same
The present invention relates to a dietary supplement, composition, nutraceutical, and/or system for inducing or treating biological responses or conditions (namely sleep or sleep disorders) which utilize ultra-low dosage amounts of vitamins, minerals, amino acids, co-enzymes, stimulants, and/or similar ingredients in a highly bio-active delivery system which bypasses first pass metabolism. In particular, the present invention relates to a nutraceutical composition/formulation which substantially bypasses first pass metabolism and such as, but not limited to, activation of the glymphatic system to facilitate clearance of neuronal metabolites from the CSF and interstitial fluids in the brain.
1. A nutraceutical composition comprising micro- or nano-quantities of the following ingredients in a preparation suitable for administration to a person in need thereof, the ingredients comprising, in combination with minerals or salts thereof comprising magnesium, sodium, potassium, calcium, chromium, copper, iron and zinc, vitamins comprising A, B1, B2, B3, B6, B12, folic acid, C, D3, E and H, at least one antioxidant, and at least one amino acid, wherein the minerals comprise, in combination, magnesium chloride, sodium ascorbate, sodium nitrite, potassium carbonate, calcium ascorbate, potassium benzoate, chromium picolinate, chromium polynicotinate, potassium sorbate, potassium iodide, calcium carbonate, iron, copper and zinc.
2. The nutraceutical composition of claim 1 , wherein the at least one antioxidant is coenzyme Q-10.
3. The nutraceutical composition of claim 1 , wherein the at least one amino acid is L-glutamine or L-arginine.
4. A nutraceutical composition comprising, in combination, magnesium or salts thereof, sodium or salts thereof, potassium or salts thereof, calcium or salts thereof, chromium, copper, iron and zinc, vitamins A, B1, B2, B3, B6, B12, folic acid, C, D3, E and H, at least one antioxidant, L-glutamine and L-arginine, wherein each of the foregoing is present in micro- or nano-quantities in a preparation suitable for oral administration to a person in need thereof, wherein the minerals comprise, in combination, magnesium chloride, sodium ascorbate, sodium nitrite, potassium carbonate, calcium ascorbate, potassium benzoate, chromium picolinate, chromium polynicotinate, potassium sorbate, potassium iodide, calcium carbonate, iron, copper and zinc.
5. The nutraceutical composition of claim 4 , wherein the nutraceutical is administered to an individual to induce enhanced sleep quality in the individual.
6. The nutraceutical composition of claim 4 , wherein the nutraceutical composition substantially avoids first pass metabolism when administered to a person in need thereof.
7. The nutraceutical composition of claim 4 , wherein the nutraceutical composition is administered to an individual to induce stage n3-NREM sleep.
8. The composition of claim 4 , wherein the short duration sleep lasts for about one hour or less.
9. A method of activating a subject's glymphatic system, comprising the step of administering a therapeutically effective amount of the composition of claim 1 by a route of administration that substantially avoids first pass metabolism.
10. A method of activating a subject's glymphatic system, comprising the step of administering a therapeutically effective amount of the composition of claim 4 by a route of administration that substantially avoids first pass metabolism.
11. A nutraceutical composition comprising micro- or nano-quantities of the following ingredients in an oral preparation suitable for oral administration to a person in need thereof, the ingredients comprising, in combination with minerals or salts thereof comprising magnesium, sodium, potassium, calcium, chromium, copper, iron and zinc, vitamins comprising A, B1, B2, B3, B6, B12, folic acid, C, D3, E and H, at least one antioxidant, and at least one amino acid, wherein the at least one amino acid is L-arginine.
12. The nutraceutical composition of claim 11 , wherein the minerals further comprise a chloride, a carbonate, an ascorbate, a nitrite, a picolinate, a polynicotinate, a benzoate or an iodide.
13. The nutraceutical composition of claim 11 , wherein the minerals comprise, in combination, magnesium chloride, sodium ascorbate, sodium nitrite, potassium carbonate, calcium ascorbate, potassium benzoate, chromium picolinate, chromium polynicotinate, potassium sorbate, potassium iodide, calcium carbonate, iron, copper and zinc.
14. The nutraceutical composition of claim 11 , wherein the at least one antioxidant is coenzyme Q-10.
15. A method of activating a subjects glymphatic system, comprising the step of administering a therapeutically effective amount of the composition of claim 12 by a route of administration that substantially avoids first pass metabolism.