Molded fluid transfer assemblies having increased working pressures and burst pressures

1. A fluid connection comprising:

a. a plurality of flexible polymeric tubes;

b. an integral fluid connector coupled to and in fluid communication with each of the plurality of tubes, wherein the fluid connector is covalently bonded to the tubes,

c. a shell disposed over and encapsulating the fluid connector, wherein the fluid connection has a working pressure of at least about 120 psi, wherein the shell is overmolded over the fluid connector such that the fluid connector is essentially encapsulated by the shell.

2. The fluid connection of claim 1 , wherein the polymeric tubes have an aseptic inner cavity, the fluid connector has an aseptic inner cavity, the inner cavity of the polymeric tubes is in fluid communication with the inner cavity of the fluid connector, and the shell is composed of a material which is non-autoclavable.

3. The fluid connection of claim 1 , wherein a coupling of the fluid connector with the plurality of tubes is the first point of failure in the working pressure of the fluid connection before addition of the shell, and wherein after addition of the shell disposed over and encapsulating the fluid connector, the coupling of the fluid connector with the plurality of tubes is not the first point of failure in the working pressure of the fluid transfer assembly.

4. The fluid connection of claim 1 , wherein at least one of the tubes comprises a biopharmaceutical tube.

5. The fluid connection of claim 1 , wherein at least one of the tubes comprises a thermoplastic elastomer.

6. The fluid connection of claim 1 , wherein at least one of the tubes comprises a reinforced silicone tube.

7. The fluid connection of claim 1 , wherein the fluid connector is integral with the tubes.

8. The fluid connection of claim 1 , wherein the fluid connector has a shape of a tee, wye, elbow, cross joint, or straight connector.

9. The fluid connection of claim 1 , wherein the outer surface of fluid connector comprises one or more surface features comprising a protrusion, a depression, a groove, a channel, or combinations thereof.

10. The fluid connection of claim 1 , wherein the shell comprises a polypropylene.

11. The fluid connection of claim 1 , wherein the shell is monolithic.

12. The fluid connection of claim 1 , wherein the shell has a hardness greater than the hardness of the fluid connector and the hardness of the tubing.

13. The fluid connection of claim 1 , wherein the shell is composed of a material that is incompatible with the tubing and the fluid connector.

14. A fluid transfer assembly comprising one or more of the fluid connections according to claim 1 .

15. An autoclavable biopharmaceutical fluid connection comprising:

a. a plurality of silicone reinforced tubes;

b. an integral silicone fluid connecter coupled to the plurality of tubes such that there is an essentially seamless transition between the inner cavity of the plurality of tubes and the fluid connector, and wherein the fluid connector is covalently bonded to the tubes; and

c. a polypropylene shell disposed over and encapsulating fluid connector, wherein the fluid connection has a working pressure of at least about 120 psi.

16. A method of forming a fluid connection, the method comprising:

a. providing a plurality of tubes;

b. integrally forming a fluid connector about the plurality of tubes, wherein the fluid connector is covalently bonded to the tubes;

c. forming a shell over and encapsulating the fluid connector, wherein the fluid connection has a working pressure of at least about 120 psi, wherein forming a shell comprises overmolding the shell over the fluid connector such that the fluid connector is essentially encapsulated by the shell.

17. The method of claim 16 , wherein forming a fluid connector comprises overmolding the fluid connector about the tubes.