Cromolyn derivatives and related methods of imaging and treatment
Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula: wherein: X is OH, C 1 -C 6 alkoxyl; Y and Z are independently selected form a C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, halogen, un-substituted or C 1 -C 6 substituted amine, 18 F, 19 F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H and X is OH.
1. A method for treating Alzheimer's disease in a subject in need thereof consisting of co-administering:
by inhalation cromolyn sodium in the form of a dry powder, and
by mouth from 1 mg to 25 mg of ibuprofen per day,
wherein the dry powder is micronized and further comprises an excipient.
2. The method of claim 1 , wherein 1 mg, 2 mg, 5 mg, 10 mg, or 25 mg of ibuprofen per day are co-administered.
3. The method of claim 1 , wherein 1 mg, 2 mg, 5 mg, or 10 mg of ibuprofen per day are co-administered.
4. The method of claim 1 , wherein 10 mg or 25 mg of ibuprofen per day are co-administered.
5. The method of claim 1 , wherein the excipient is lactose monohydrate.
6. The method of claim 1 , wherein 0.05 to 0.5 mg/kg per day of cromolyn sodium are administered.
7. The method of claim 1 , wherein the dry powder further comprises a pharmaceutically acceptable carrier.
8. A method for treating Alzheimer's disease in a subject in need thereof consisting of co-administering:
by inhalation cromolyn sodium in the form of a dry powder, and
by mouth 10 mg of ibuprofen per day,
wherein the dry powder is micronized and further comprises an excipient.
9. The method of claim 8 , wherein the excipient is lactose monohydrate.
10. The method of claim 8 , wherein 0.05 to 0.5 mg/kg per day of cromolyn sodium are administered.
11. The method of claim 8 , wherein the dry powder further comprises a pharmaceutically acceptable carrier.