Methods relating to the use of remote ischemic conditioning
The invention contemplates, inter alia, the use of remote ischemic conditioning in the treatment of a variety of disorders.
1. A method comprising
performing remote ischemic conditioning (RIC) on a limb of a subject having cancer to treat the cancer,
wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein a second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.
2. The method of claim 1 , wherein the subject is receiving a second therapy.
3. The method of claim 2 , wherein the second therapy is administered at less than a maximum tolerable dose.
4. The method of claim 2 , wherein the second therapy is administered at greater than the maximum tolerable dose.
5. The method of claim 2 , wherein the second therapy is antibody-based therapy.
6. The method of claim 2 , wherein one or more RIC regimens is performed within 48 hours, within 24 hours, within 12 hours, within 6 hours, within 4 hours, within 2 hours, within 1 hour or within 30 minutes of the administration of the second therapy.
7. The method of claim 1 , wherein the cancer is not associated with an ischemia/reperfusion injury.
8. A method comprising
performing remote ischemic conditioning (RIC) on a subject having an infectious disease to treat the infectious disease,
wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein a second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.
9. The method of claim 8 , wherein the infectious disease is bacterial meningitis.
10. The method of claim 8 , wherein the infectious disease is not associated with an ischemia/reperfusion injury.
11. A method comprising
performing remote ischemic conditioning (RIC) on a subject having a lysosomal storage disorder to treat the lysosomal storage disorder,
wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein a second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.
12. The method of claim 11 , wherein the lysosomal storage disorder is GM1 gangliosidosis or Tay-Sachs disease.
13. The method of claim 11 , wherein the subject is receiving a second therapy that is enzyme replacement therapy.
14. The method of claim 13 , wherein one or more RIC regimens is performed within 48 hours, within 24 hours, within 12 hours, within 6 hours, within 4 hours, within 2 hours, within 1 hour or within 30 minutes of the administration of the enzyme replacement therapy.
15. The method of claim 11 , wherein the lysosomeal storage disorder is not associated with an ischemia/reperfusion injury.
16. A method comprising
performing remote ischemic conditioning (RIC) on a subject having kidney disease that is not associated with ischemia/reperfusion injury, to treat the kidney disease,
wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein a second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.
17. A method comprising
performing remote ischemic conditioning (RIC) on a subject having transplant rejection that is not associated with ischemia/reperfusion injury, to reduce or alleviate the transplant rejection,
wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more and wherein the second or subsequent cycle begins upon conclusion of reperfusion of a previous cycle.
18. A method comprising
performing remote ischemic conditioning (RIC) on a subject having cancer to treat the cancer,
wherein RIC comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle has a blood flow occlusion duration of one minute or more, wherein a second or subsequent cycle begins upon the conclusion of reperfusion of a previous cycle, and
wherein the subject is receiving a second therapy which is an antibody-based therapy.
19. The method of claim 18 , wherein one or more RIC regimens is performed within 48 hours, within 24 hours, within 12 hours, within 6 hours, within 4 hours, within 2 hours, within 1 hour or within 30 minutes of the administration of the antibody-based therapy.