Methods for modifying a hydrophobic polymer surface and devices thereof
Aspects of the invention include methods for modifying a surface of a non-porous hydrophobic polymer substrate having a backbone containing electrophilic linkages. In practicing methods according to certain embodiments, a liquid composition having a nucleophilic reagent and a catalyst is contacted with the surface of the non-porous hydrophobic polymer substrate and maintained in contact with the surface of the polymer substrate in a manner sufficient to convert at least a portion of the surface from hydrophobic to hydrophilic while retaining the mechanical and optical properties of the polymer substrate. Substrates, including containers, having one or more hydrophilic surfaces and kits suitable for practicing the subject methods are also described.
1. A method of modifying a surface of a non-porous hydrophobic polymer substrate, the method comprising:
contacting the surface of the non-porous hydrophobic polymer substrate with a liquid composition comprising a nucleophilic reagent and a catalyst, wherein the non-porous hydrophobic polymer substrate comprises a polymer having a backbone containing electrophilic linkages; and
maintaining the composition in contact with the surface of the hydrophobic polymer substrate in a manner sufficient to convert at least a portion of the surface from hydrophobic to hydrophilic by transesterification while retaining the mechanical and optical properties of the polymer substrate.
2. The method according to claim 1 , wherein maintaining comprises maintaining the composition in contact with the polymer substrate at a temperature that is 10° C. or more below the glass transition temperature of the polymer.
3. The method according to claim 1 , wherein maintaining comprises maintaining the composition in contact with the polymer substrate at room temperature.
4. The method according to claim 1 , wherein the polymer substrate is polyester or polycarbonate.
5. The method according to claim 1 , wherein the nucleophilic reagent is a polyol selected from ethylene glycol and glycerol.
6. The method according to claim 1 , wherein the catalyst is a base selected from a guanidine-containing compound and a hydroxide.
7. The method according to claim 1 , wherein the hydrophobic polymer substrate is selected from the group consisting of a culture dish, blood collection tube, test tube, centrifuge tube, culture tube, microtube, syringe, fluidic conduit, chromatography column walls, medical tubing, cap, pipette, microtiter plate, flask, beaker, straw, catheter, cuvette, polymeric lens, jar, can, cup, bottle, rectilinear polymeric container, food storage container, intravenous drug delivery bag and blood transfusion bag.
8. The method according to claim 1 , wherein the hydrophobic polymer substrate is a surface of a container.
9. The method according to claim 8 , wherein maintaining comprises converting an interior surface of the container from hydrophobic to hydrophilic, while retaining the exterior surface of the container as hydrophobic.
10. A method of modifying an interior surface of a polymer container, the method comprising:
contacting an interior surface of a polymer container with a composition comprising a nucleophilic reagent and a catalyst, wherein the polymer container comprises a polymer having a backbone containing electrophilic linkages; and
maintaining the composition in contact with the interior surface of the polymer container in a manner sufficient to convert at least a portion of the surface from hydrophobic to hydrophilic by transesterification while retaining the mechanical and optical properties of the polymer container.
11. The method according to claim 10 , wherein maintaining comprises maintaining the composition in contact with the interior surface of the polymer container at a temperature that is 10° C. or more below the glass transition temperature of the polymer.
12. The method according to claim 10 , wherein maintaining comprises maintaining the composition in contact with the interior surface of the polymer container at room temperature.
13. The method according to claim 10 , wherein maintaining comprises maintaining the composition in contact with the interior surface of the polymer container for 30 minutes or less.