Diagnostic anti-CD95L antibody
The present invention relates to a specific CD95L antibody and to the use thereof in the diagnosis of a cancer disease.
1. A monoclonal anti-CD95L antibody or a functional fragment thereof, comprising: a heavy chain comprising a CDRH1 as shown in SEQ ID NO: 1, a CDRH2 as shown in SEQ ID NO: 2, and a CDRH3 as shown in SEQ ID NO: 3, and a light chain comprising a CDRL1 as shown in SEQ ID NO: 4, a CDRL2 as shown in SEQ ID NO: 5, and a CDRL3 as shown in SEQ ID NO: 6.
2. The monoclonal anti-CD95L antibody or a functional fragment thereof according to claim 1 , comprising:
a heavy chain variable region comprising the amino acid sequence as shown in SEQ ID NO: 7, or an amino acid sequence having a sequence identity of at least 95% thereof, and/or a light chain variable region comprising the amino acid sequence as shown in SEQ ID NO: 8, or an amino acid sequence having a sequence identity of 95% thereof.
3. The monoclonal anti-CD95L antibody or a functional fragment thereof according to claim 1 , comprising a heavy chain comprising the amino acid sequence as shown in SEQ ID NO: 9, or an amino acid sequence having a sequence identity of at least 95% thereof, and/or a light chain comprising the amino acid sequence as shown in SEQ ID NO: 10, or an amino acid sequence having a sequence identity of at least 95% thereof.
4. The monoclonal antibody according to claim 1 , wherein a label group is covalently attached to the antibody.
5. A pharmaceutical composition comprising the antibody according to claim 1 , optionally together with a pharmaceutically acceptable carrier.
6. The monoclonal antibody according to claim 1 , which is a full-length immunoglobulin or a functional immunoglobulin fragment selected from the group consisting of Fab, Fab′, F(ab′)2, Fv, and single chain antibodies (scFv).
7. The monoclonal antibody according to claim 2 , which is a full-length immunoglobulin or a functional immunoglobulin fragment selected from the group consisting of Fab, Fab′, F(ab′)2, Fv, and single chain antibodies (scFv).
8. The monoclonal antibody according to claim 5 , which is a full-length immunoglobulin or a functional immunoglobulin fragment selected from the group consisting of Fab, Fab′, F(ab′)2, Fv, and single chain antibodies (scFv).
9. The monoclonal antibody according to claim 2 , wherein a label group is covalently attached to the antibody.
10. The monoclonal antibody according to claim 5 , wherein a label group is covalently attached to the antibody.
11. The monoclonal antibody according to claim 2 , comprising a heavy chain variable region comprising the amino acid sequence having a sequence identity of at least 98% to the amino acid sequence of SEQ ID NO: 7, and/or a light chain variable region comprising the amino acid sequence having a sequence identity of at least 98% to the amino acid sequence of SEQ ID NO: 8.
12. The monoclonal antibody according to claim 5 , comprising a heavy chain variable region comprising the amino acid sequence having a sequence identity of at least 98% to the amino acid sequence of SEQ ID NO: 9, and/or a light chain variable region comprising the amino acid sequence having a sequence identity of at least 98% to the amino acid sequence of SEQ ID NO: 10.