Compounds and methods for treating bacterial infections
The present invention encompasses compounds and methods for treating urinary tract infections.
1. A compound of structural Formula XXIV
wherein:
X is selected from the group consisting of hydrogen, OD 2 , SD 2 , and ND z ;
Z is O 4 ;
Y is oxygen 4 ;
D 2 , D 4 , D 5 are independently selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl;
n is an integer from 1 to 10;
A is independently selected from the group consisting of C, CD 6 and N;
D 6 is independently selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl;
D 24 is selected from the group consisting of hydrogen, halogen, hydrocarbyl, and substituted hydrocarbyl;
D 25 and D 26 is selected from the group consisting of hydrogen, —NHCONH 2 , —COOMe, and —CONHMe, or D 25 and D 26 can optionally form a cycloalkyl or heterocyclo ring;
D z is independently selected from the group consisting of hydrogen hydrocarbyl, substituted hydrocarbyl, —COD x , —COND x D x SO 2 D x , and —CO 2 D x ; and
D x is independently selected from the group consisting of hydrogen, —ND 4 D 5 , or an optionally substituted alkyl, cycloalkyl, heterocycle, or aryl.
2. The compound of claim 1 , wherein X is OR 2 ; and Z is O.
3. The compound of claim 1 , wherein D 24 is hydrocarbyl.
4. The compound of claim 3 , wherein D 24 is methyl.
5. The compound of claim 1 , wherein D 25 and D 26 form a cycloalkyl or heterocyclo ring.
6. A method of treating a urinary tract infection, the method comprising administering a compound of claim 1 to a subject in need thereof.
7. The method of claim 6 , wherein the subject is further administered a bactericidal composition.
8. A method of reducing the resistance of a bacterium to a bactericidal compound, the method comprising administering a compound of claim 1 to a subject in need thereof.